摘要
目的探讨COX-2和P-gp在B细胞型非霍奇金淋巴瘤(B-NHL)的表达及意义。方法采用免疫组化S-P法检测COX-2及P-gp在70例B-NHL和25例良性淋巴结病变组织中的表达。结果COX-2蛋白及P-gp在B-NHL中的阳性表达率分别为42.9%(30/70)和34.3%(24/70),在对照组的阳性率表达率分别为8%(2/25)和4%(1/25),差异具有显著性(P<0.05)。B-NHL患者COX-2和P-gp的表达呈正相关(r=0.758,P<0.05)。COX-2和P-gp均阴性表达的B-NHL患者化疗疗效及5年生存率均高于两者阳性表达患者。COX-2和P-gp共同表达为独立于IPI的独立预后因素,与患者的生存期呈负相关(χ2=13.363,P<0.0001)。结论COX-2和P-gp在B-NHL的发生发展中具有协同作用,且两者阳性表达提示患者预后不良。
Objective This study was designed to observe the expression and clinical significance of COX-2 and P-gp in B cell Non-Hodgkin＇S lymphoma（B-NHL）. Methods The expression of COX-2 and P-gp in 70 cases of B-NHL and 25 cases of benign lymph node pathological changes were detected by immunohistochemical streptavidin-biotinperoxidase method. Results The expression rate of COX-2 and P-gp in B-NHL was 42. 9% （30/70）and 34. 3% （24/70）respectively, higher than control group（P〈0. 05）. COX-2 expression was positively correlated with P-gp expression（r=0. 758 ,P〈0.05）. The efficacy and 5-year survival rate of patients with COX-2 and Pgp negative expression was higher than that of both positive expression. COX mode showed COX- 2 and P-gp were the independent poor prognosis index（χ^2 = 13. 363, P〈0. 0001）. Conclusion COX-2 and P-gp play a cooperation role with each other in the development and progression of B- NHL, and the high expression of COX-2 and P-gp indicates that poor prognosis.
出处
《江西医学院学报》
2007年第1期37-39,43,共4页
Acta Academiae Medicinae Jiangxi
