摘要
采用组织学和图像分析技术，研究了小鼠经腹腔注射交感神经损毁剂6-羟多巴胺后小鼠体重和小肠绒毛长度、V／C比值、绒毛宽度以及黏膜厚度的变化。结果表明，注射6-羟多巴胺组与对照组小鼠相比，体重下降（约3．4％）；小肠绒毛变短（5．6％～19．4％），V／C比值减少（0．88％～24．1％），绒毛变窄（8．8％～24．7％）、黏膜厚度变薄（4．4％～16．9％），其中空肠的绒毛长度和黏膜厚度减少较明显，而十二指肠和回肠的V／C比值和绒毛宽度减少较明显。提示交感神经的活动可影响小肠的黏膜结构，从而影响肠道的消化吸收功能。
The changes of body weight,intestinal villus length,V/C value, villus width and mucous thickness in mice,which were injected intraperitoneally with the sympathetic denervation dose of 6-OHDA, were investigated. The results showed that the mice＇s body weigh decreased by about 3.4%after 6-OHDA treatment. COUS 24. 1 cant ickn ,8.8 the Compared with the control group, the intestinal villus length,V/C value,villus width and muess in the 6-OHDA-treated group were significantly reduced by 5. 6%- 19. 4%, 0. 88%- %-- 24.7 % and 4.4 % -- 16.9 %, respectively. Among them, the reductions were very signifivillus length and mucous thickness of jejunum,and the V/C values and villus lengths of both ileum and duodenum. The results suggest that the sympathetic nerves play a role in modulation of structures and functions of the intestinal mucosa.
出处
《中国兽医科学》
CAS
CSCD
北大核心
2007年第3期260-263,共4页
Chinese Veterinary Science
基金
国家自然科学基金项目(30471247
30671514)
中国农业大学科研启动基金项目(2006041)
