摘要
目的评价经皮椎间盘内医用臭氧注射治疗腰椎间盘突出症围术期不用抗生素预防感染的可行性。方法将术前体温、三大常规、C-反应蛋白及胸片均正常的72例腰椎间盘突出症患者随机分成两组:预防组35例,术前30min给予先锋霉素Ⅴ2.0g静脉滴注;对照组37例,不使用抗生素。随后均在DSA下用一次性21G酒精针穿刺病变椎间盘,注射浓度为40μg/ml臭氧气体6～10ml,退针至椎间孔附近椎旁组织内注入臭氧10ml。术后第3天复查三大常规和C-反应蛋白。结果术后所有患者体温均在正常范围,局部皮肤无红肿热痛,无深部肌肉压痛和椎体叩击痛等。对两组间术后白细胞总数、中性粒细胞百分比及C-反应蛋白超过正常值患者进行统计学处理均无显著性差异。结论经皮椎间盘内医用臭氧注射治疗腰椎间盘突出症围术期不需预防性应用抗生素。
Objective To evaluate the feasibility of no antibiotic administration to prevent infection during the perioperative period ofpercutaneous intradiscal ozone-injection for treatment of lumbar disc herniation. Methods Seventy-two patients with lumbar disc herniation but normal body ternperature as well as normal results of three routine tests （blood, wrine, stoos） and C-reactive protein （CRP） level were randomly divided into two groups. The patients in prophylaxis group were given cephalothinV （2.0 g） intravenous 30 min before the operation, and the control group did not use any antibiotics. All the patients were injected with 6-10 ml ozone （40 μg/ml） for medical use into the discs with 21G needles under fluoroscopic guidance, followed by 10 ml ozone into the paravertebral space. Three days later the general examinations and CRP measurement were repeated. Results No infection was found in these patients, nor were any significant differences noted in the results of the examinations between the two groups after controlling in patients with above-normal white blood cell count, neutrophil percentage and CRP level. Conclusion Prophylaxis antibiotics is not necessary during the perioperative period of percutaneous intradiscal ozone injection for lumbar disc heriniation.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2007年第3期384-386,共3页
Journal of Southern Medical University
关键词
腰椎间盘突出症
感染
臭氧
抗生素
围手术期
lumbar disc herniation
infection
ozone
anti-bacterial agents
perioperative period
