期刊文献+

雌激素受体α的表达及其甲基化与泌尿生殖系肿瘤

原文传递
导出
摘要 DNA甲基化是哺乳动物细胞中遗传外修饰,与基因转录失活有关。泌尿生殖系肿瘤中部分雌激素受体(ERα)不表达或表达减少,与ERα基因启动子CpG岛高度甲基化有关。DNA甲基化抑制剂能使ERα恢复表达,可望用于治疗泌尿生殖系肿瘤。
出处 《国际泌尿系统杂志》 2007年第2期212-214,共3页 International Journal of Urology and Nephrology
  • 相关文献

参考文献21

  • 1Wong YF, Chung TK, Cheung TH, et al. Methylation of P16INK4A in primary gynecologic malignancy. Cancer Lett, 1999,136 (2): 231- 235.
  • 2Lau KM, Laspina M, Long J, et al. Expression of Estrogen Receptor(ER) - α and ER - β in Normal and Malignant Prostatic Epithelial Cells: Regulation by Methylation and Involvement in Growth Regulation. Cancer Res,2000,60:3175 -3182.
  • 3Paech K, Webb P, George G, et al. Differential ligand activation of estrogen receptors Era and ERβat AP1 sites. Science, 1997,277:1508-1510.
  • 4Shoker BS, Jarvis C, Sibson DR, et al. Oestrogen receptor expression in the normal and pre - cancerous breast. Pathol J, 1999, 188 (3):237 - 244.
  • 5Kurebayashi J, Otsuki T, Kunisue H, et al. Expression Levels of Estrogen Receptor - α, Estrogen Receptor - β, Coactivators, and Corepressors in Breast Cancer. Clin Cancer Res,2000,6:512.
  • 6Iwamoto I, Fujino T, Douchi T, et al. Association of Estrogen Receptor α and β - Adrenergic Receptor Polymorphisms With Endometrial Cancer. Obstet. Gynecol,2003,102:506.
  • 7Kaklamanos IG, Bathe OF, Franceschi D, et al. Expression of receptors for estrogen and progesterone in malignant colonic mucosa as a prognostic factor for patient survival. J Surg Oncol, 1999,72 (4): 225-229.
  • 8Shah Y, Li L, Yah C. Expression of estrogen receptors and progestrogen receptors in transitional cell carcinoma of bladder. Chin Med J (Engl). 1998;111(2):191-192.
  • 9米华,甘俊常.性激素及其受体与膀胱癌[J].临床荟萃,2000,15(11):525-526. 被引量:5
  • 10Baskci A, Kirkali Z, Tuzel E, et al. Prognostic Significance Of Estrogen Receptor Expression in Superficial Transitional Cell Carcinoma of Urinary Bladder. Eur Uro, 2002,41:342 - 345.

二级参考文献9

共引文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部