摘要
目的观察瑞香素对大鼠肺孢子虫肺炎(PCP)的治疗效果。方法皮下注射醋酸泼尼松龙建立PCP大鼠模型。将受试大鼠随机分为正常对照组(A)、未治疗对照组(B)、TMP-SMZ对照组(C)、瑞香素治疗组(D)和青蒿素对照组(E)5组。各组从第7周开始灌服相应药物5d,停药后观察1周,用肺质量/体质量比和肺组织虫荷量考核疗效。结果PCP大鼠6周内的病死率为16.7%;满6周者抽样进行病原、病理检查证实均已成功诱导PCP。A、B、C、D、E组受试大鼠的平均肺质量/体质量比分别为0.75、1.05、0.77、0.77和0.85,B^E4组受试大鼠肺组织虫荷量分别为1490、74、339和219个/mg。统计学分析显示,经瑞香素治疗的大鼠平均肺质量/体质量比、肺虫荷量均明显低于未治疗对照组(分别为P<0.05和P<0.01),效果虽不如TMP-SMZ,但与青蒿素疗效相似(P>0.05)。结论瑞香素对大鼠PCP有显著疗效,效果与青蒿素接近。
Objective To evaluate the efficacy of dephnetin in the treatment of pneumocystis carinii pneumonia （PCP） in rat models. Methods The PCP animal model was made by subcutaneously injecting prednisolone acetate in female Wistar rat. All experimental rats were randomly divided into 5 groups： group A was normal control ; group B was control with no drug for treatment; group C was control given TMP-SMZ; group D was rats given dephnetin; group E was control given dihydroarteminsinin（DHA）. The efficacy of dephnetin on the treatment of PCP was evaluated by altration in ratio of lung weight to body weight and the burden of Pneumocystis carinii. Results The mortality of the experimental rats immunosuppressed by prednisolone acetate was 16.7% in six weeks. The mean ratios of lung weight to body weight in groups A ～ E were 0.75, 1.05, 0.77, 0.77, and 0.85 respectively. And the mean counts of Pneumocystis carinii cyst/mg of lung in groups B ～ E were 1 490, 74,339, and 219 respectively. The mean ratio of lung weight to body weight and the mean count of Pneumocystis carinii cyst/rag of lung in groups C, D and E were significantly lower than those of the control group B with no drug for therapy（P〈0.05 and P 〈 0.01 ）. Although the efficacy of dephnetin was not better than those of TMP-SMZ, there was no difference between the efficacy of dephnetin and DHA. Conclusion Dephnetin is effective in the treatment of PCP in rat models, and its therapeutic efficacy is similar to that of DHA.
出处
《首都医科大学学报》
CAS
2007年第1期85-88,共4页
Journal of Capital Medical University
关键词
肺孢子虫肺炎
大鼠模型
瑞香素
pneumocystis carinii pneumonia（PCP）
rat model
dephnetin
