摘要
纤维化是机体创伤修复的一种类型,各种类型的肝脏疾病均可引起肝纤维化最终导致肝硬化。星状细胞是肝纤维化形成的中心环节,其活化的主要特征之一是合成大量的细胞外基质。近年来的研究证实,肝纤维化和早期肝硬化是可逆的,此文综述肝纤维化形成机制,并探讨目前及将来抗肝纤维化的治疗方法。
The response to injury is one of wound healing and subsequently fibrosis, Injury and wounding lead to cirrhosis ultimately in many patients （although not all patients）. Recent literature indicates that the hepatic stellate cell is the central component in the fibrogenie process. Stellate cells undergo a transformation during injury that has been termed activation. Activation is complex and multifaceted, hut one of its most prominent features is the synthesis of large amounts of extracellular matrix. It is noteworthy that even advanced fibrosis （or cirrhosis） is reversible. This article emphasizes mechanisms underlying fibrogenesis, and reviews current antifibrotie therapies as well as potential future approaches.
出处
《国际消化病杂志》
CAS
2007年第1期24-27,共4页
International Journal of Digestive Diseases
关键词
肝纤维化
星状细胞
细胞因子
治疗
Hepatic fibrosis
Hepatic stellate cell
Cytokine
Therapy
