摘要
目的研究胆木Nauclea officinalis的生物碱成分。方法95％乙醇提取胆木带皮茎枝的化学成分，采用反复硅胶柱色谱、Sephadex LH20凝胶柱色谱和C-18反相硅胶柱色谱分离纯化，通过光谱分析鉴定化合物的结构。结果从醋酸乙酯部位分离得到11个成分，其中9个为吲哚类生物碱，2个喹啉酮类生物碱，分别鉴定为：牛眼马钱托林碱（angustoline，Ⅰ）、19-乙氧基牛眼马钱托林碱（19-O-ethylangustoline，Ⅱ）、3-S-3，4-二氢牛服马钱托林碱（3-S-3，4-dihydroangustoline，Ⅲ）、3-R-3，4-二氢牛眼马钱托林碱（3-R-3，4-dihydroangustoline，Ⅳ）、naucleamide A（Ⅴ）、异长春花苷内酰胺（strictosamide，Ⅵ）、喜果苷（vincosamide，Ⅵ）、6′-异乙酰基长春花苷内酰胺（6′-acetylstrictosamide，Ⅷ、2′-异乙酰基长春花苷内酰胺（2′acetyl-strictosamide，Ⅸ）、短小蛇根草苷（pumiloside，Ⅹ）、3-表短小蛇根草苷（3-epi-pumiloside，Ⅺ）。结论化合物Ⅰ～Ⅺ均为首次从该植物中分离得到。
Objective To investigate the alkaloidal constituents of Nauclea officinalis, an anti-inflammatory and antibacterial traditional Chinese herb. Methods The alkaloids were isolated and purified by silica gel, Sephadex LH20, and C-18 ODS column chromatography repeatedly, and their structures were identified by spectral analysis. Results Eleven alkaloids were isolated from the stems of N. officinalis and their structures were identified as angustoline （Ⅰ）, 19-O-ethylangustoline （Ⅱ）, 3-S-3, 4-dihydroangustoline （Ⅲ）, 3-R-3, 4-dihydroangustoline （Ⅳ）, naucleamide A （Ⅴ）, strictosamide （Ⅵ）, vincosamide （Ⅶ）, 6＇-acetyl-strictosamide （Ⅷ）, 2＇-acetyl-strictosamide （ Ⅸ）, pumiloside （Ⅹ）, 3-epi-pumiloside （Ⅺ）. Conclusion Compounds Ⅰ-Ⅺ are isolated from this plant for the first time.
出处
《中草药》
CAS
CSCD
北大核心
2007年第2期170-173,共4页
Chinese Traditional and Herbal Drugs
关键词
乌檀属
胆木
吲哚类生物碱
Nauclea L.
the stems of Nauclea officinalis Pierrc ex Pitard
indole alkaloids
