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PUMA在大肠癌中的作用及临床意义

Functions of PUMA and its Clinical Significance in Human Colorectal Carcinoma
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摘要 PUMA具有强大的促凋亡功能，其分子结构、转录机制的深入研究，使其有望成为肿瘤治疗新靶点，现对其特点、结构、分子机制以及在大肠癌中研究进展作一综述。 PUMA has strong functions to prompt apoptosis. A number of studies have been done to describe its molecular structure and transcription mechanism, which make it or serve as a objective target for cancer therapies. This article briefly reviews the progress of its characteristics, structure, molecular mechanism in colorectal cancer.
作者 李春香 姜争 傅松滨
机构地区 哈尔滨医科大学基础医学院 哈尔滨医科大学第一临床医院
出处 《国际遗传学杂志》 CAS 2007年第1期45-47,63,共4页 International Journal of Genetics
关键词 PUMA 大肠癌 基因治疗 PUMA Colorectal carcinoma Gene therapy
分类号 R735 [医药卫生—肿瘤]
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参考文献29

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  • 2Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell, 2001,7: 683-694.
  • 3Han JW, Flemington C, Houghton AB, et al. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. PNAS, 2001,98: 11318-11323.
  • 4Huang DCS, Strasser A. BH3-only proteins-essential initiators of apoptotic cell death. Cell, 2000, 103 : 839-842.
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  • 8Bergamaschi D, Samuels Y, Jin B, et al. ASPP1 and ASPP2:common activators of p53 family members.Mol Cell Biol, 2004, 24 :1342-1350.
  • 9Melino G, Bernassola F, Ranalli M, et al. p73 induces apoptosis via PUMA transactivation and Bax-mitochondrial translocation.J Biol Chem, 2004, 279: 8076-8083.
  • 10Yu J, Tivari S, Steiner P, et al. Differential apoptotic response to the proteasome inhibitor Bortezomib in Bax-defieient and p21-deficient colon cancer cells. Cancer Biol Ther, 2003, 2: 694-699.
国际遗传学杂志
2007年 第1期

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