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异常隐窝灶与大肠癌

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摘要 大肠癌是发病率较高的恶性肿瘤,其发生、发展涉及多因素、多阶段和多途径。目前,大肠癌的“正常上皮增生上皮腺瘤癌转移癌”的序列发病路径已广为接受。异常隐窝灶(aberrant crypt foci,ACF)是目前大肠癌在光镜下可见的最小、最早的黏膜损伤,其在遗传、表观遗传、免疫组化和组织病理等方面的改变都影响着肿瘤发生,可以说是其癌前病变。了解ACF的特征性变化及其与大肠癌发生的关系,对进一步认识和预防大肠癌有重要意义。尽管有关ACF的报道很多,却鲜见相关研究进展综述,本文即将此方面做一介绍。
出处 《中华消化杂志》 CAS CSCD 北大核心 2008年第9期647-648,共2页 Chinese Journal of Digestion
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  • 1Ping Yuan~1 Meng Hong Sun~2 Jin Sheng Zhang~1 Xiong Zeng Zhu~2 Da Ren Shi~2 ~1Department of Pathology,Medical College of Fudan University,~2Department of Pathology,Cancer Hospital/Cancer Institute,Fudan University,Shanghai 200032,ChinaDr.Ping Yuan Studying Province.studying in Medical College of Fudan University,worked in Department of Pathology,Wannan Medical College,having eighteen papers published..APC and K-ras gene mutation in aberrant crypt foci of human colon[J].World Journal of Gastroenterology,2001,7(3):352-356. 被引量:21
  • 2Jian Qi,You-Qing Zhu,Mei-Fang Huang,Dong Yang.Hypermethylation of CpG island in O^6-methylguanine-DNA methyltransferase gene was associated with K-rasG to A mutation in colorectal tumor[J].World Journal of Gastroenterology,2005,11(13):2022-2025. 被引量:2
  • 3[2]Morson BC.Precancerous lesions of the colon and rectum.Classification and controversial issues.JAMA 1962; 179:316-321
  • 4[3]Jeevaratnam P,Cottier DS,Browett PJ,Van De Water NS,Pokos V,Jass JR.Familial giant hyperplastic polyposis predisposing to colorectal cancer:a new hereditary bowel cancer syndrome.J Pathol 1996; 179:20-25
  • 5[4]Estrada RG,Spjut HJ.Hyperplastic polyps of the large bowel.Am J Surg Pathol 1980; 4:127-133
  • 6[5]Goldman H,Ming S,Hickock DF.Nature and significance of hyperplastic polyps of the human colon.Arch Pathol 1970; 89:349-354
  • 7[6]Snover DC.Serrated polyps of the large intestine.Semin Diagn Pathol 2005; 22:301-308
  • 8[7]Torlakovic E,Skovlund E,Snover DC,Torlakovic G,Nesland JM.Morphologic reappraisal of serrated colorectal polyps.Am J Surg Pathol 2003; 27:65-81
  • 9[8]Urbanski SJ,Kossakowska AE,Marcon N,Bruce WR.Mixed hyperplastic adenomatous polyps-an underdiagnosed entity.Report of a case of adenocarcinoma arising within a mixed hyperplastic adenomatous polyp.Am J Surg Pathol 1984; 8:551-556
  • 10[9]Longacre TA,Fenoglio-Preiser CM.Mixed hyperplastic adenomatous polyps/serrated adenomas.A distinct form of colorectal neoplasia.Am J Surg Pathol 1990; 14:524-537

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