摘要
合成了4个未见报道的含肉桂酰胺类化合物9a～9d,初步评价了它们的α-糖苷酶抑制活性.这些化合物均具有α-糖苷酶抑制活性,是一类结构新颖的α-糖苷酶抑制活性化合物,其中,化合物9b和9c的活性高于阳性对照药物阿卡波糖.
Four new cinnamic amides 9a-9d were synthesized, and their preliminarily inhibitory activities for α-glucosidase were evaluated. All of these compounds displayed inhibitory activities of α-glucosidase, and are a new structural type of α-glucosidase inhibitory compounds. The inhibitory activity of 9b and 9c was higher than those of control drug acarbose.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2007年第1期77-81,共5页
Chinese Journal of Organic Chemistry
基金
湖南省教育厅青年基金(No.06qj050)资助项目.
关键词
糖尿病
肉桂酰胺
合成
α-糖苷酶抑制活性
diabetes
cinnamic amide
synthesis
α-glucosidase inhibitory activity
