摘要
目的:探讨乌贼墨制品对60Coγ辐射损伤小鼠造血功能的影响。方法:采用造血祖细胞体外培养方法、实验血液学技术等方法,检测模型小鼠脾指数及胸腺指数、骨髓有核细胞数(BMNC)、骨髓造血干细胞生成数(CFU-S)、粒-单系祖细胞集落生成数(CFU-GM)、外周血象和血清超氧化物岐化酶(SOD)活力。结果:乌贼墨制品能够有效拮抗60Coγ辐射损伤模型小鼠体内BMNC、CFU-S、CFU-GM、外周WBC及血清SOD活力的降低,并显著促进其恢复;但对外周血RBC、PLT、Hb均无显著影响。结论:乌贼墨制品能够显著促进辐射损伤小鼠骨髓粒系造血作用。
Objective： To investigate the activation effects of sepia product on hematopoietic function in ^60 Coγ irradiated mice. Methods： Model mice of hematopoietic system impairment were induced by whole body ^60 Coγ irradiaion with the lethal dose of 8.0 Gy and then given different dosage of sepia products respectively. Spleen and thymus indexes, numbers of bone marrow nucleated cells （BMNC）, colony-forming units in spleen （CFU-S）, colony-forming units of granulocyte and monocyte（CFUGM）, peripheral blood pictures and serum SOD activity in model mice were assayed respectively. Results： Sepia products could resist the decrease of BMNC（p 〈 0.05, p 〈 0.01）, CFU-S（p 〈 0.05, p 〈 0.01）, CFU-GM（p 〈 0.01）, and peripheral WBC （p 〈 0.01 ） and promote the restoration of those indices mentioned above in model mice significantly （p 〈 0.05, p 〈 0.01）, but have no significant effects on peripheral RBC, PLT and Hb respectively. Conclusion： Sepia production has significant promoting effects on hemapoiecsis.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2007年第2期293-297,共5页
Food Science
基金
863目标导向项目(2006AA09Z444)
新世纪优秀人才支持计划项目(NCET-04-0642)
