摘要
用自由基引发3-丙烯酰胺基苯硼酸（AAPBA）、N，N-二甲基丙烯酰胺（DMAA）和丙烯酰胺（AAm）共聚交联制得新型三嵌段水凝胶P（AAPBA-CO-DMAA-CO-AAm），与传统的两嵌段聚合物相比，该凝胶具有良好的糖敏感特性，在质量浓度200ms／dL以上有较高的糖响应特性，这一数值接近糖尿病病人的血糖阈值，其溶胀度达10倍以上，同时糖响应时间缩短到2～3h．振荡实验结果表明，所得凝胶对糖呈现出良好的刺激．响应特性．
Glucose-sensitive porous poly （3-acrylamidophenylboronic acid-co-N, N-dimethylacrylamide-coacrylamide） [ P（AAPBA-co-DMAA-co-AAm） ] hydrogels were prepared by radical copolymerization in dimethyl sulphoxide（DMSO） solution. At Physiological pH condition（pH 7.4, 37 ℃ ）, the sensitivity of the Hdro gels to the sugaroncentration was investigated, and the influence of the component on the swelling ratio was studied at the same time. At the given range, with the increase of the contents of AAPBA and AAm in the gels. Compared with conventional biblock polymer, this hydrogel preserved an excellent sensibility to sugarconcentration and could response when the mass concentration of glucose is above 200 mg/dL, which approaches to diabetic＇s threshold of blood sugar. The swelling ratio of this hydrogel reached more than 10 times. At the same time, the response time to concentration of glucose decreased to 2-3 h. The results of surging experiment show the porous hydrogel possesses an excellent stimulate-response capability to sugar. Therefore, these novel porous Hdrogels have potential for the controlled release of drugs, especially for the micro molecular drugs.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2007年第2期376-381,共6页
Chemical Journal of Chinese Universities
关键词
苯基硼酸
糖敏感
凝胶
溶胀
响应
Phenylboronic acid
Sugar-sensitivity
Gel
Swelling
Responsivity
