摘要
The chiral stationary pahse of 3,5-dimethylphenylcarbamates of cellulose chemically bonded to 3-aminopropyl silica gel at the 6-position of the glucose units was prepared.The racemates of tebuconazole were resolved on the new immobilized chiral stationary phase,and the influences of modifiers(alcohols,THF and chloroform) in the mobile phase on the resolution were investigated.The chromatographic conditions were optimized.The results show that the new immobilized chiral stationary phase exhibits a good stereoselectivity to tebuconzole.The best resolution of 1.51 of tebuconazole was obtained by using hexane/2-propanol/ THF(volume ratio 90∶5∶5) as the mobile phase on a 150 mm column.
The chiral stationary pahse of 3,5-dimethylphenylcarbamates of cellulose chemically bonded to 3-aminopropyl silica gel at the 6-position of the glucose units was prepared. The racemates of tebuconazole were resolved on the new immobilized chiral stationary phase, and the influences of modifiers（ alcohols, THF and chloroform） in the mobile phase on the resolution were investigated. The chromatographic conditions were optimized. The＇ results show that the new immobilized chiral stationary phase exhibits a good stereoselectivity to tebuconzole. The best resolution of 1.51 of tebuconazole was obtained by using hexane/2-propanol/ THF （volume ratio 90： 5： 5） as the mobile phase on a 150 mm column.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2007年第2期258-260,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20375045)
甘肃省自然科学基金(批准号:3ZS041-A25-23)
中国科学院'西部之光'(2003)项目资助
关键词
键合
手性固定相
手性拆分
戊唑醇
Immobilization
Chiral stationary phase
Chiral resolution
Tebuconazole
