摘要
目的：观察丙氨瑞林对子宫内膜癌的治疗作用。方法：对诊刮确诊的１７例子宫内膜癌病人，予丙氨瑞林７００μｇ，ｉｍ，ｑｄ×７ｄ，用药前后作性激素测定及组织学检查。结果：绝经妇女用药后血中ＦＳＨ和ＬＨ下降（Ｐ＜０．０１和＜０．０５），雌二醇、孕酮及睾丸酮变化不明显。其中１３例内膜样腺癌用药后有丝分裂指数明显下降（Ｐ＜０．０１），有丝分裂指数变化与癌周内膜之反应有关。呈增生反应癌周内膜癌组织有丝分裂指数下降值明显高于呈萎缩状态癌周内膜。结论：丙氨瑞林治疗子宫内膜癌后能降低ＦＳＨ和ＬＨ水平，对子宫内膜癌尤其是雌激素依赖性内膜癌有一定疗效。
AIM :To assess the role of alarelin(Ala)in treatment of endometrial cancer.METHODS:Seventeen patients with endometrial cancer received Ala 700 μg im qd for 7 d.Sex hormones and histological controls were measured to evaluate the therapeutic effects of Ala. RESULTS:In postmenopausal women,there was a marked reduction in FSH and LH levels after Ala therapy,but the changes of estradiol, progesterone,and testosterone were not obvious,Mitotic index(MI) in 13 patients with endometrioid cancer was markedly decreased(P<0.01).The change of MI has a correlation with the endometrium response around cancer tissue.The reduction of MI in proliferative endometrium was more obvious than that in atrophic endometrium.CONCLUSION:Ala therapy may evoke the FSH and LH level breakdown in the patients with endometrial cancer. Ala has some therapeutic effect for endometrial cancer,especially for hormone-dependent endometrial cancer.
出处
《新药与临床》
CSCD
北大核心
1996年第4期194-196,共3页
关键词
丙氨瑞林
子宫内膜肿瘤
性激素类
药物疗法
Alarelin
endometrial neoplasms
hormone-dependent neoplasms
pituitary hormone releasing hormones
mitotic index
sex hormones
