他汀类药物对高胆固醇血症患者炎症因子和红细胞膜脂肪酸的影响被引量：21

The influence of statins on the blood inflammatory factors and fatty acid of erythrocyte membrane inhypercholesterolemic patients.

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摘要目的比较瑞舒伐他汀与辛伐他汀的调脂疗效及其对血液中炎症因子、红细胞膜上脂肪酸的影响。方法选择2005年6月至12月南昌大学医学院第二附属医院心内科门诊诊断的30例高胆固醇血症(HC)患者(LDL-C>3.64mmol/L)接受8周的双盲对照治疗,分别服用瑞舒伐他汀或辛伐他汀,开盲后按随机号每种药物选择15名患者。患者均于治疗前、治疗4周末及8周末采空腹静脉血测血脂4项、高敏C-反应蛋白(hs-CRP)、白介素-6。同时随机选择瑞舒伐他汀组中7例高胆固醇血症患者,另选7名血脂正常成人为对照,观察红细胞膜脂肪酸(FA)的构成比在治疗前后的变化。分别在治疗前与治疗4周末采血测定红细胞膜FA。结果(1)治疗4周末2组血清LDL-C、总胆固醇(TC)、hs-CRP水平均明显降低;治疗8周末LDL-C、TC未见进一步下降,但hs-CRP仍有进一步降低。(2)与对照组相比,高胆固醇血症组(HC)红细胞膜上饱和脂肪酸(SFA)所占比例明显更高,而多不饱和脂肪酸(PUFA)、ω-3脂肪酸比例明显较低。治疗4周后SFA明显降低,而PUFA、ω-3脂肪酸的比例明显增高。结论(1)2组药物降低炎症因子的作用是独立于调脂作用的。(2)瑞舒伐他汀10mg/d治疗能有效降低高胆固醇血症患者血清LDL-C与TC水平。其调脂效果与20mg/d辛伐他汀相似。(3)血脂异常影响红细胞膜上各类脂肪酸的含量及比例,2组药物均可有效改善HC患者红细胞膜上不同脂肪酸的构成比例。 Objective To observe the influence of treatment with rosuvastatin or simvastatin on the inflammatory factors and components of membrane FA in hypercholesterolemic patients. Methods hypercholesterolemic patients （ LDL-C 〉 3. 64 mmol/L）received 8-week double blind comparisons treatment. After treatment we randomly selected 15 patients for each group. The fasting serum lipid was measured at the end of g-week and 8-week,and the serum hs-CRP and IL-6 were measured too. Meanwhile seven hypercholesterolemic patients from rosuvastatin group and seven ortholiposis out-patients were included. These patients were treated with statins for 4 weeks. The erythrocytes before and after treatment were kept to be measured the FA. Results （ 1 ） Compared with the pretreatment, the level of LDL-C, TC, hs-CRP remarkably reduced in two treatment groups at the end of g-week therapy. These inflammatory parameters did not further reduced, but hs-CRP reduced further at the end of 8-week therapy. （2） The percent age of SFA was obviously higher in hypercholesterolemic group than ortholiposis group. On the other hand, PUFA and to-3 FA were obviously lower. After g-week treatment the percent age of SFA reduced, while PUFA and to-3 FA increased significantly in hypercholesterolemic group. Conclusion （ 1 ） Statins reducing inflammatory factors is independent of lipid-modifying ability. （2） Rosuvastatin treatment can effectively reduce the level of LDL-C and TC, and no significant difference in the effect is observed between two treatment groups. （3）The erythrocyte membrane FA proportion was obviously different in hypercholesterolemic group from ortholipo-sis group. Statins treatment could make the proportion of FA in erythrocyte membrane restore normal.

作者龚艺徐劲松苏海王卫

机构地区南昌大学医学院第二附属医院

出处《中国实用内科杂志》 CAS CSCD 北大核心 2007年第3期193-195,共3页 Chinese Journal of Practical Internal Medicine

基金江西省卫生厅资助课题(2003307)

关键词高胆固醇血症高敏C-反应蛋白白介素-6 脂肪酸 Hypercholesterolemia High sensitivity C-reactive protein Interleukin-6 Fatty acid

分类号 R5 [医药卫生—内科学]

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