摘要
以(S)-乳酸甲酯为原料,与对甲苯磺酰氯反应制备(S)-对甲苯磺酰乳酸甲酯,再与对苯二酚反应制备(R)-2-(4-羟基苯氧基)丙酸乙酯,然后与3,4-二氟苯腈反应制备(R)-2-[4-(4-氰基-2-氟苯氧基)苯氧基]丙酸乙酯,经水解、酯化合成氰氟草酯,总收率49%,化学纯度95%,光学纯度98%。
The starting material （S）-methyl lactate was esterified with p-toluenesulfonyl chloride to give （S）-methyl p-toluenesu/fonyl lactate, which in turn reacted with hydroquinone to give ethyl R-2-（4-hydroxyphenoxy） propionate, and the resulting intermediate reacted with 3,4-difluorobenzonitrile giving ethyl（R）-2-[4-（4-cyano-2- fluorophenoxy）phenoxy ]propionate. The target product cyhalofop butyl was obtained by hydrolysis and esterificafion of ethy] （R）-2-[4-[4-cyano-2-fluorophenoxy）phenoxy]propionate. The total yield was 49%, the chemical and optica]purity was 95% and 98%, respectively.
出处
《农药研究与应用》
2007年第1期23-25,共3页
Agrochemicals Research & Application
