摘要
报道了合成超高效除草剂炔草酯的中间体R(+)对羟基苯氧基丙酸炔丙酯的方法。以(S)-(-)乳酸甲酯为原料,先与对甲苯磺酰氯反应制备S-对甲苯磺酰乳酸甲酯,再与对苯二酚和丙炔醇反应,制备R(+)对羟基苯氧基丙酸炔丙酯,总收率76%。旋光度为[α]2D5=+37.5。
R（＋）-2-（4-hydroxyphenoxy） propionic acid propynyl ester is an important intermediates of herbicide R- clodinafop-propargyl. A new method for synthesizing R （＋）-2-（4-hydroxyphenoxy） propionic acid propynyl ester is reported in the paper. The starting material S-methyl lactate was condensed with p-toluenesulfonyl chloride to give L- methyl p-toluenesulfonyl lactate, and L-methyl p-toluenesulfonyl lactate reacted with hydroquinone and propargyl alcohol to give the target product R （＋）-2-（4-hydroxyphenoxy） propionic acid propynyl ester. The total yield and optical activity （[α]D^25） of the product is 76% and ＋37.5, respectively.
出处
《精细化工中间体》
CAS
2006年第2期29-31,共3页
Fine Chemical Intermediates
