摘要
目的探讨低氧诱导因子-1α(HIF-1α)在原发性颊黏膜鳞癌中的表达变化及其意义。方法通过免疫组织化学方法,了解HIF-1α在60例原发性颊黏膜鳞癌中的表达,分析其阳性表达水平与颊癌临床分期、病理分级以及预后等临床病理因素之间的关系。结果不同分化程度的颊癌组织中HIF-1α的阳性表达水平差异没有统计学意义(P>0.05);而早、晚期颊癌组织中,HIF-1α阳性表达水平的差异存在统计学意义(P<0.05);有淋巴结转移的患者,其原发灶肿瘤组织中HIF-1α的阳性表达水平高于无淋巴结转移者(P<0.05);预后差的颊癌组织中,HIF-1α的阳性表达水平明显高于预后好组(P<0.05)。结论颊癌中HIF-1α的阳性表达水平与疾病发展进程密切相关,其是颊癌患者预后不良的重要生物学指标。
Objective To study the expression of hypoxia inducible factor-1α （HIF-1α） protein in buccal carcinoma and its biological significance. Methods The expression of HIF-1α was assayed by means of immunohistochemical technique in 60 patients. The expression of HIF-1α and its relationship with clinical pathological factors and tumor prognosis were investigated and analyzed statistically by Kruskal-Wallis Test. Results The positive rate of HIF-1α was higher in T3-4 than T1-2, and the positive rate of HIF-1α was higher in patients with cervical lymphatic metastasis than patients without cervical lymphatic metastasis. Patients with HIF-1α over-expression had poor prognosis than patients with HIF-1α lower expression. Conclusion Over-expression of HIF-1α is a vital biological marker in prognosis of buccal cancer.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2007年第1期5-7,共3页
West China Journal of Stomatology
基金
国家自然科学基金资助项目(30471903)
关键词
低氧诱导因子-1Α
颊黏膜鳞癌
免疫组化
hypoxia inducible factor-1α
buccal carcinoma
immunohistochemistry
