摘要
目的研究血红素氧合酶-1(HO-1)在正常人牙髓组织中的表达,探讨其分布与功能的关系。方法临床因阻生或正畸拔除的健康第三磨牙或前磨牙的牙髓,用免疫组织化学SABC法进行染色,检测HO-1在牙髓组织中的表达情况。结果 HO-1在牙髓血管内皮细胞和成牙本质细胞呈现阳性表达,在部分牙髓成纤维细胞和幼稚牙髓细胞中呈阳性或弱阳性表达。结论提示HO-1在牙髓血流调控、牙本质形成及牙髓细胞代谢和分化中可能起一定的作用。
Objective To study the expression of heme oxygenase-1 （HO-1）in dental pulp tissue and to find out the relationship of distribution and function of HO-1. Methods 30 pulp tissues were obtained from clinically extracted human healthy premolars and third molars. The expression of HO-1 in dental pulp was detected by means of SABC immunohistochemical technology. Results HO-1 immunoreactivity was observed in vascular endothelial cells, edontoblasts and some fibroblasts cells. Conclusion The distribution of HO-1 in normal human dental pulp suggests that HO-1 may play an important role in pulp flow regulation, dentin production and its calcifying; it also may play some roles in dental pulp cells metabolism and differentiation.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2006年第2期104-105,109,共3页
West China Journal of Stomatology
基金
浙江省自然科学基金资助项目(Y204316)
关键词
血红素氧合酶
牙髓
免疫组化
heme oxygenase
dental pulp
immunohischemistry
