摘要
目的制备酮洛芬-羟丙基-β-环糊精包合物,考察2-羟丙基-β-环糊精对药物的增溶以及包合物在高温、高湿、强光照射下的稳定性。方法溶液-搅拌法制备包合物;相溶解度法考察2-羟丙基-β-环糊精对药物的增溶,以酮洛芬的含量为测定指标,分别对酮洛芬-羟丙基-β-环糊精包合物和混合物进行强光照射、高温和高湿试验。结果酮洛芬的溶解度从0.165mg/mL增加到38.69mg/mL,且在高温、高湿和强光照射条件下,包合物中酮洛芬的含量没有明显变化,而混合物中酮洛芬的含量有明显的下降。结论2-羟丙基-β-环糊精可以增大酮洛芬的溶解度,提高酮洛芬对温度、湿度和光照的稳定性。
OBJECTIVE To prepare the complex including ketoprofen-hydroxypropyl-β-cyclodextrin （Hp-β-CD） and investigate the solubility and stability of the complex under the strong light, high temperature and humidity. METHODS The complex was prepared by agitation method; phase-solubility method was used to evaluate the solubilizing. Using the content of ketoprofen as an index, a set of tests, such as tests under strong light and under high temperature or humidity, were taken. RESULTS The solubility of ketoprofen was increased from 0. 165mg/mL to 38.69mg/mL. Under the affecting factors of light, temperature and humidity, the content of ketoprofen complex was not obviously changed. For physical mixture, however, the content was significantly decreased. CONCLUSION 2-HP-β-CD could increase the solubility and stability of ketoprofen.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2007年第1期39-42,共4页
Chinese Journal of Modern Applied Pharmacy
