摘要
本文对胆碱脂酶脂解部位的组氨酸、丝氨酸等残基间的氢键问题做了CNDO/2的量子化学计算,从理论上讨论了乙酰胆碱酶催化水解反应中谁作为亲核基团向底物进攻的问题,得到一些有益的结果。
In this papert,we conducted the quantum chemistry calculation (CNDO/2) to the hydrogen bonding between histicline and serine residues of the cholinesterase ester degradation sites.From the theoretical point of view,we discussed which of the nucleopophilic group that attacts the substrate in the acetylcholine catalized hydrolysis reaction,and we obtained some meaningful results.
出处
《东北师大学报（自然科学版）》
CAS
CSCD
1990年第3期85-90,共6页
Journal of Northeast Normal University(Natural Science Edition)
关键词
胆碱脂酶
催化反应
量子化学
氢键
Choline trase
Enzyme Catalization
Hydrogen bonding
CNDO/2
