摘要
目的:评价盐酸拓扑替康+顺铂治疗小细胞肺癌的疗效和不良反应。方法:治疗初治小细胞肺癌70例,盐酸拓扑替康0.75mg/m2,静脉滴注d1～5,顺铂20mg/m2dl～3,每4周重复疗程。结果:CR11例(16.7%)PR36例(51.4%),NC23例(32.9%),PD3例(4.3%)。结论:盐酸拓扑替康+顺铂治疗初治小细胞肺癌安全有效。
OBJECTIVE： To evaluate the curative effect and toxicity of topotecan hydrochioride plus DDP for small cell lung cancer （SCLC）. METHODS： 70 patients with SCLC were treated with topotecan hydrochlofide 0.75mg/m^2 iv gtt from day 1 to day 5 and DDP 20mg/m^2 iv gtt from day 1 to day 3. Course of treatment was repeated every 4 weeks. RESULTS： Therewere 11 CR cases （16.7%）, 36 PR cases （51.4%）, 23 NC cases （32.9%） and 3 PD cases （4.3%） . CONCLUSION： Topotecan hydrochloride plus DDP is safe and effective in the treatment of SCLC.
出处
《中国医院用药评价与分析》
2007年第1期70-71,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
盐酸拓扑替康
顺铂
联合化疗
小细胞肺癌
topotecan hydrochloride
cisplatin （DDP）
combined chemotherapy
small cell lung cancer
