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难治及复发重型再生障碍性贫血研究现状 被引量：2

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摘要 重型再生障碍性贫血（SAA）是免疫介导的，以骨髓造血干细胞（HSC）及造血微环境损伤、骨髓脂肪化和外周血全血细胞减少为特征的造血功能衰竭综合征。临床上表现为严重的感染、出血和贫血。目前，免疫抑制治疗（IST）与同胞供者骨髓移植（BMT）并列为SAA标准疗法。临床研究证实抗淋巴细胞球蛋白（ALG）／抗胸腺细胞球蛋白（ATG）联合环孢素（CsA）的强化IST有效率可达70％～80％。尽管如此，仍有一部分患者属IST难治或IST后复发，特别是前者，预后较差。我们对IST难治和复发SAA的研究现状作一综述。
作者 黄文阳 郑以州
机构地区 中国医学科学院、中国协和医科大学血液学研究所、血液病医院
出处 《中华血液学杂志》 CAS CSCD 北大核心 2007年第2期137-140,共4页 Chinese Journal of Hematology
关键词 重型再生障碍性贫血 复发 难治 骨髓造血干细胞 抗胸腺细胞球蛋白 抗淋巴细胞球蛋白 造血功能衰竭 全血细胞减少
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献27

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同被引文献9

  • 1张宏丽（综述）,郑以州（审校）.重复应用ALG／ATG治疗重型再生障碍性贫血的研究现状[J].国际输血及血液学杂志,2007,30(1):58-61. 被引量：2
  • 2Zheng Y, Liu Y, Chu Y. Immunosuppressive therapy for acquired severe aplastic anemia (SAA) : a prospective comparason of four different regimens. Exp Hematol, 2006; 34:826-831.
  • 3Tichelli A, Passweg J, Nissen C, et al. Repeated treatment with horse antilymphocyte globulin for severe aplastic anaemia. Br J Haematol, 1998, 100:393-400.
  • 4di Bona E, Rodeghiero F, Bruno B, et al. Rabbit antithymocyte globulin (r-ATG) plus cyclosporine and granulocyte colony stimulating factor is an effective treatment for aplastic anemia patients unresponsive to a first course of intensive Haematol, 1999,107:330-334.
  • 5Rosenfeld S, Follmann D, Nunez O, et al. Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome. JAMA, 2003,289:1130- 1135.
  • 6Frickhofen N, Heimpel H, Kaltwasser JP, et al. Antithymocyte globulin with or without cyclosporin A : 11 -year follow-up of a randomized trim comparing treatments of aplastic anemia. Blood, 2003, 101: 1236-1242.
  • 7Zheng Y, Liu Y, Chu Y. Immunosuppressive therapy for ac- quired severe aplastie anemia(SAA) :a prospective comparason of four different regimens [J]. Exp Hematol, 2006, 34: 826- 831.
  • 8郑以州,储榆林,邵宗鸿,张益枝,陈桂彬.抗淋巴细胞球蛋白联合环孢霉素A治疗重型再生障碍性贫血的临床研究[J].中华血液学杂志,1999,20(4):175-177. 被引量：23
  • 9肖海燕,刘驰,郑春梅,刘锋.二次抗淋巴细胞球蛋白/抗胸腺细胞球蛋白治疗重型再生障碍性贫血4例临床分析[J].临床血液学杂志,2011,24(3):303-306. 被引量：3

引证文献2

二级引证文献13

中华血液学杂志
2007年 第2期

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