重复应用ALG/ATG治疗重型再生障碍性贫血的研究现状
被引量:2
摘要
抗胸腺细胞球蛋白(ATG)/抗淋巴细胞球蛋白(ALG)治疗重型再生障碍性贫血疗效显著,但约20%~30%的患者无效和约35%的患者复发。其中部分患者行重复疗程治疗仍可取得疗效。本文就初次IIST失败或复发的判定标准、病理机制、进行重复疗程的实施方案及其临床疗效等方面作一综述。
出处
《国际输血及血液学杂志》
CAS
2007年第1期58-61,共4页
International Journal of Blood Transfusion and Hematology
参考文献23
-
1Bacigalupo A, Broccia G, Corda G, et al. Antilymphocyte globulin, cyclosporin, and granulocyte colony-stimulating factor in patients with acquired severe aplastic anemia (SAA): a pilot study of the EBMT SAA Working Party. Blood, 1995,85 (5):1348-1353.
-
2Frickhofen N, Heimpel H, Kaltwasser JP, et al. Antithymocyte glodulin with or without cyclosporin A: 11-year follow-up of a randomized trial comparing treatments of aplastic anemia. Blood,2003,101 (4) : 1236-1242.
-
3Rosenfeld S, Follmann D, Nunez O, et al. Antithymocyte Globulin and Cyclosporine for Severe Aplastic Anemia: association between hematologic response and long-term outcome. JAMA,2003,289(9) :1130-1135.
-
4Calado RT, Pintao MC, Rocha V, et al. Lack of mutations in the human telomerase RNA component (hTERC) gene in Fanconi's anemia. Haematologica, 2004,89(8) : 1012-1013.
-
5Vulliamy T, Marrone A, Szydlo R, et al. Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC. Nat Genet,2004,36(5) :447-449.
-
6Fogarty PF, Yamaguchi H, Wiestner A, et al. Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet, 2003,362 (9396) :1628-1630.
-
7Brodsky RA, Chen AR, Brodsky I, et al. High-dose cyclophlsphamide as salvage therapy for severe aplastic anemia. Exp Hematol, 2004,32 ( 5 ) : 435-440.
-
8Di Bona E, F. Rodeghiero,B Brumo,et al. Rabbit antithymocyte globulin (r-ATG) plus cyclo- sporine and granulocyte colony stimulating factor is an effective treatment for aplastic anaemia patients unresponsive to a first course of intensive immunosupperssive therapy. Br J Haematol, 1999,107 : 330-334.
-
9Kojima S, Inaba J, Yoshimi A, et al. Unrelated donor marrow transplantation in children with severe aplastic anaemia using cyclophosphamide, antithymocyte globulin and total body irradiation. British Journal of Haematology, 2001,114 (3) : 706-711.
-
10Tichelli, A, Passweg, J, Nissen, C. Repeated treatment with horse antilymphocyte globulin for severe aplastic anaemia. Br J Haematol, 1998,100(2) : 393-400.
二级参考文献11
-
1张之南主编.血液学诊断及疗效标准.第2版.北京:科学出版社,1998.33-38.
-
2Nakao S,Yamaguchi M,Shintaro S,et al.Interferon γgene expression in unstimulated bone marrow mononuclear cells predicts a good response to cyclosporine therapy in aplastic anemia.Blood,1992,79(10):2532-2535.
-
3Gottwald E,Muller O,Polten A.Semiquantitative reverse transcriptionpolymerase chain reaction with the Agilent 2100 Bioanalyzer.Electrophoresis,2001,22(18):40164022.
-
4Laver J,Castro-Malaspina H,Kernan NA,et al.In vitro interferon-gamma production by cultured T-cells in severe aplastic anemia:correlation with granulomonopoietic inhibition in patients who response to anti-thymocyte globulin.Br J Haematol,1988,69(4):545-550.
-
5Sloand E,Kim S,Maciejewski JP,et al.Intracellular IFN-γin circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia.Blood,2002,100(4):1185-1191.
-
6Viale M,Merli A,Bacigalupo A.Analysis at the clonal level of T-cell phenotype and functions in severe aplastic anemia patients.Blood,1991,78(5):1268-1274.
-
7Lamb JR,Bal V,Mendez-Samperio P,et al.Stress proteins may provide a link between the immune response to infection and autoimmunity.Int Immunol,1989,1(2):191-196.
-
8Trieb K,Sztankay A,Hermann M,et al.Do heat shock proteins play a role in Graves' disease? Heat shock protein specific T cells from Graves' disease thyroids to not recognize thyroid epithelial cells.J Clin Endocrinol Metab,1993,77(2):528-535.
-
9Takami A,Nakao S,Tatsumi Y,et al.High inducibility of heat shock protein 72(hsp72) in peripheral blood mononuclear cells of aplastic anemia patients:a reliable marker of immune-mediated aplastic anemia responsive to cyclosporine therapy.Br J Haematol,1999,106(2):377-384.
-
10Sztankay A,Trieb K,Lucciarini P,et al.Interferon gamma and iodide increase the inducibility of 72kD heat shock protein in cultured human thyroid epithelial cells.J Autoimmunity,1994,7(2):219-230.
共引文献4
-
1陈昀,徐从高.再生障碍性贫血免疫抑制疗法疗效预测指标的评价[J].中华血液学杂志,2006,27(11):783-785. 被引量:2
-
2陈昀,徐从高,郭农建,黄平,肖东杰,丁卜同,葛林阜.干扰素γ联合HLA-DRB1*1501预测再生障碍性贫血免疫抑制疗法的应用价值[J].中华内科杂志,2007,46(10):846-849. 被引量:5
-
3徐希娴.国内免疫抑制剂治疗苯中毒性再生障碍性贫血的现状[J].中国工业医学杂志,2007,20(6):401-403.
-
4王志生.造血生长因子、甲泼尼龙联合十一酸睾酮、环孢素A治疗急性再障30例疗效观察[J].实用临床医药杂志,2010,14(8):90-91. 被引量:1
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-
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-
2许崇艳.再生障碍性贫血的免疫抑制治疗[J].中国实验血液学杂志,2005,13(2):348-352. 被引量:24
-
3张岩,马小建,汪奇伟,何书.细胞因子网络在再生障碍性贫血发病中的作用[J].实用儿科临床杂志,2005,20(9):888-889. 被引量:11
-
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-
5黄永兰,黄绍良.儿童再生障碍性贫血免疫介导发病机制及治疗进展[J].中华儿科杂志,2006,44(2):153-155. 被引量:13
-
6陈纯,方建培,黄绍良,钟凤仪.免疫抑制治疗儿童重型再生障碍性贫血54例疗效分析[J].中华儿科杂志,2006,44(11):841-844. 被引量:11
-
7黄文阳,郑以州.难治及复发重型再生障碍性贫血研究现状[J].中华血液学杂志,2007,28(2):137-140. 被引量:2
-
8[1]Puff P.Controversies in the management of vesicoureteric reflux[J].Ir Med,1992,85(4 suppl):4-6.
-
9[2]Jichun Chen,PhD.Animal Models for Acquired Bone Mar-row Failure Syndromes[J].Clinical Medicine & Research,2005,3(2):102-108.
-
10[5]Kahl C,Leisenring W,Deeg HJ,et al.Cyclophosphamide and antithy moeyte globulin as a conditioning regimen for allogeneic marrow transplantation in patients with aplastic anaemia:A long-term follow-up[J].Br J Haematol,2005,130 (5):747-751.
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-
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-
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-
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-
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-
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-
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-
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-
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-
9方敏.康力龙治疗再生障碍性贫血的效果及其不良反应发生情况分析[J].中国医学创新,2018,15(17):133-136. 被引量:1
-
10高静.重症再生障碍性贫血感染的护理及预防[J].西部中医药,2018,31(11):108-110. 被引量:8
-
1储榆林,张茂宏,吴梓梁,林果为,徐世荣,李蓉生,周霭祥,殷德厚.再生障碍性贫血的药物治疗[J].中华血液学杂志,1999,20(4):208-210. 被引量:93
-
2逯秀玲,王昕,王雯,王红艳,邵宗鸿.ALG/ATG治疗重型再生障碍性贫血后血清病皮疹的观察及护理[J].天津护理,1999,7(6):236-237.
-
3刘雪梅,陈文新.ALG/ATG治疗严重型再生障碍性贫血疗效观察[J].包头医学院学报,2004,20(3):213-214. 被引量:1
-
4肖海燕,刘驰,郑春梅,刘锋.二次抗淋巴细胞球蛋白/抗胸腺细胞球蛋白治疗重型再生障碍性贫血4例临床分析[J].临床血液学杂志,2011,24(3):303-306. 被引量:3
-
5夏凌辉,江汇娟,方峻,刘芳,张纯,宋善俊.ALG/ATG为主的免疫抑制剂治疗重型再生障碍性贫血的临床研究[J].华中科技大学学报(医学版),2006,35(2):253-255. 被引量:6
-
6卢洁(译),郑明华(译),陈永平(校).减少聚乙二醇干扰素α-2a和病毒唑剂量在慢性丙型肝炎患者重复治疗过程中的影响[J].胃肠病学和肝病学杂志,2007,16(6):531-531.
-
7母靖岚.西地兰治疗心力衰竭的临床观察和护理配合[J].中国社区医师(医学专业),2011,13(25):255-256. 被引量:3
-
8赵晓婷,梁晓宇,赵文丽.放射性碘治疗甲状腺功能亢进的护理[J].家庭护士(下半月),2007,5(10):34-35.
-
9赵秀云,刘卫校,丁华.三阶段重复治疗骨质疏松症疗效观察[J].中国煤炭工业医学杂志,2005,8(3):262-262. 被引量:1
-
10邵宗鸿.再生障碍性贫血的免疫治疗[J].医师进修杂志,2001,24(6):6-7. 被引量:6