摘要
目的：探索美托洛尔对老年高血压病左室肥厚有否逆转作用。方法：高血压ＩＩ期病人３８例（男性２９例，女性９例；年龄６７±ｓ５ａ）采用美托洛尔２５～５０ｍｇ，ｐｏ，ｔｉｄ，共１０～１６ｍｏ。相似病例３０例（男性２３例，女性７例；年龄６６±６ａ）采用氢氯噻嗪２５～５０ｍｇ，ｐｏ，加螺内酯２０～４０ｍｇ，ｐｏ，ｔｉｄ，共１０～１６ｍｏ作为对照。结果：美托洛尔组治疗后左室后壁厚度、室间隔厚度、舒张期左室内径、左室心肌重量指教均显著下降（Ｐ＜０．０１），小轴缩短率与射血分数下降速率均显著升高（Ｐ＜０．０１）。对照组无上述效应。结论：美托洛尔确有使老年高血压病人左室肥厚减轻的作用。
AIM:To observe the effect of reversal of left ventricular hypertrophy by metoprolol in elderly hypertensive patients.METHODS:Thirty-eight elderly patients(M 29,F9 ;age 67±s 5 a)with stage II hypertension received metoprolol 25-50 mg,po,tid,for 10-16 mo.A similar group of 30 patients(M 23,F 7;age 66 ±6 a)received hydrochlorothiazide 25-50 mg po,tid and spironolactone 20-40 mg,po,tid,for 10-16 mo. RESULTS:Metoprolol group showed decreases in LVIFWT(left ventricular posterior wall thickness,12.9±1.9 mm to 10.9±1.6 mm),IVST (interventricular septal thickness,13.0 ±2.0 mm to 10.8 ±1.4 mm),LVDd(left ventricular diastolic dimension,6.0±0.6 mm to 5.1±0.5mm),LVMI(left ventricular mass index,151 ±19g/m2 to 110 ±15g/m2)all decreased(P<0.01),FS(fractlonal shortening,35%±5% to 40%±5%),EF(ejection fraction velocity of descent,49 ±14mm/s to 55±21 mm/s)all increased(P<0.01).Control group showed no such responses. CONCLUSION:Metoprolol reversed left ventricular hypertrophy in elderly hypertensive patients.
出处
《新药与临床》
CSCD
北大核心
1996年第3期132-134,共3页
关键词
美托洛尔
高血压
心脏肥大
药物疗法
metoprolol
hypertension
heart hypertrophy
hydrochlorothiazide
spironolactone
