摘要
目的探讨抗中性粒细胞胞质抗体（ANCA）在系统性红斑狼疮（SLE）伴肺间质病变（ILD）中的临床意义。方法用间接免疫荧光法（IIF）及免疫印迹法方法，检测97例SLE患者血清中的ANCA、抗dsDNA抗体、多种自身抗体及补体。采用全胸片及肺高分辨率CT（HRCT）检查，了解97例SLE患者伴ILD的情况。结果①97例SLE患者26例ANCA阳性，均为核周型（pANCA），阳性率为27％。（2）ANCA阳性组患者的抗dsDNA抗体的增高、补体（C3、C4）的下降及血沉（ESR）增高与ANCA阴性组相比，差异均有统计学意义（P〈0．01）。（3）6例ANCA阳性组患者，HRCT显示其中20例伴ILD（77％），71例ANCA阴性组患者，伴ILD30例（42％），ANCA阳性组的ILD发病率明显高于阴性组，两组差异有统计学意义（P〈0．01）。结论ANCA阳性的SLE患者。对判断SLE活动性及伴ILD具有一定的临床价值。
Objective To study the diagnostic value of antineutrophil cytoplasmic antibodies （ANCA） on interstitial lung disease （ILD） in systemic lupus erythematosus. Methods The expression of seral ANCA, anti double-stranded DNA antibodies, other auto-antibodies and complements in 97 lupus patients were tested by indirect immumofluorescence （IIF） and Western blotting. Ninety-seven lupus patients had chest radiography and lung high-resolution computed tomography （HRCT） done to help evaluating the severity of ILD. Results （1）The expression of ANCA in serum of 26 lupus patients was postive （all were perinuclear ANCA） with a posfive rate of 27%. （2）The 26 ANCA-positive patients had higher titers of anti ds-DNA antibodies, lower levels of complements （C3, C4） and higher erythrocyte sedimentation rate compared to ANCA negative patients （P〈 0.01）. （3）In those 26 ANCA-positive patients, 20 had ILD （77%）. In the other 71 ANCA-negative patients, 30 had ILD （42%）. The prevalence of ILD of ANCA-positive patients was higher than ANCA negative patients （P〈 0.01）. Conclusion The postive expression of ANCA in lupus patients is related to more active disease and higher frequencey of ILD.
出处
《中华风湿病学杂志》
CAS
CSCD
2007年第2期99-101,共3页
Chinese Journal of Rheumatology
关键词
抗体
抗中性白细胞胞质
红斑狼疮
系统性
肺间质病变
Antibodies, antineutrophil cytoplasmic
Lupus erythematosus, systemic
Interstitial lung disease
