摘要
目的研究蝙蝠葛碱对肾上腺素所致药物性高血压大鼠的影响．方法各组给药前均先给肝素钠500U单位。模型组注射生理盐水（Saline）10mL／kg、Ver组（0．98mL／kg剂量给药组）、低荆量组（2mg／kg）、中剂量组（4mg／kg）、高剂量组（8mg／kg）3个剂量给药组，在注射相应药物之后1～3min之内，注射重酒石酸去甲肾上腺素注射液0．18mL／kg．标记给药后各组大鼠的血压变化．结果Dau2，4，8mg／kg和Ver组注射Dau及Ver后。血压下降明显，Dau8mg／kg效果最显著平均动脉压均值降至12．9kPa．Dau4，8mg／kg组和Ver组与Control组比较，统计学差异显著P〈0．01．给予NA后，Dau2，4mg／kg组及Vet组血压均有所上升，Dau4mg／kg组和Ver组升高幅度相似，Dau 8 mg／kg组血压上升幅度不足Control组一半（平均动脉压均值为17．6kPa）．且Dau4，8mg／kg组和Ver组与Control组比较。有显著差异P〈0．01．结论提示Dau可以降低正常大鼠血压。不同浓度的Dau对NA引起的大鼠血压升高有明显的对抗作用．
Objective The experiment aims to study the effects of Dauricine（Dau） on the hypertension rats caused by Noradrenaline（NA）. Methods After the administration of 500 μ of Na to each group, the medicine is injected to the following groups respectively： model group（Saline 10 mL/kg）, Ver group （Ver 0.98 mL/ kg）, low groups, mid and high purity（Dau 2 mg/kg）（Dau 4 mg/kg）（Dau 8 mg/kg） respectively. 1- 3 minutes later, NA is injected（0.18 mL/kg）. Finally we note the change of rats＇ blood pressure. Results After the injection of Dau and Ver, the blood pressure of the Dau groups of 2, 4, 8 mg/kg and that of Ver group depressed conspicuously, in which the Dau group 8 mg/kg is the most significant （12.9 kPa）. Compared of control group with the Dau groups of 4, 8 mg/kg ＆ Vet group, the statistics difference is clear （P〈0.01）. In the post-administration of NA period, hypertension can be seen in the groups of Dau 2, 4 mg/kg and Ver. Among them, there is similarity between the groups of Dau 4 mg/kg and Vet. And the rising range of Dau 8 mg/kg is less than half of the control group（17.6 kPa）. The distinct difference lies in the comparison between groups of Dau 4, 8 mg/kg, Ver and Control（P 〈 0.01）. Conclusion The injection of Dau has great effects on depressing the blood pressure of the normal rats, NA effects are obviously restrained by Dau with different purities.
出处
《北华大学学报（自然科学版）》
CAS
2007年第1期65-67,共3页
Journal of Beihua University（Natural Science）
