摘要
A series of succinate-derived macrocyclic amides（1） was synthesized via ring-closing metathesis（RCM） as the key step. The substrate included 12 to 15 members. The metathesis precursors were obtained from the amide coupling of ten-butyl 3-carboxyhex-5-enoate（2） with numerous side-chain aikenylated amino acid esters of general type（3） derived from L-lysine and L-ornithine.
A series of succinate-derived macrocyclic amides（1） was synthesized via ring-closing metathesis（RCM） as the key step. The substrate included 12 to 15 members. The metathesis precursors were obtained from the amide coupling of ten-butyl 3-carboxyhex-5-enoate（2） with numerous side-chain aikenylated amino acid esters of general type（3） derived from L-lysine and L-ornithine.
基金
Supported partly by Key Program of Ministry of Education of China(No. 104112)
