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七氟醚预处理对大鼠局灶性脑缺血-再灌注损伤的保护作用 被引量：3

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摘要 目的观察七氟醚预处理对大鼠局灶性脑缺血-再灌注损伤的保护作用。方法32只雄性SD大鼠随机均分为四组,假手术组仅分离血管,不留置线栓;Sevo1、Sevo2和对照组分别在缺血前吸入2%、3%七氟醚和纯氧30min。用左颈内动脉尼龙线线栓法使大脑中动脉阻闭120min,拔出尼龙线恢复再灌注。观察再灌注24h后神经功能损害改变并评分,然后处死动物取大脑行2,3,5-氯化三苯基四氮唑(TTC)染色以测量脑梗死体积。结果缺血-再灌注损伤后对照组大鼠神经功能损害较Sevo1和Sevo2组更明显(P<0.05或P<0.01)。缺血-再灌注损伤24h后Sevo1组和Sevo2组脑梗死体积和梗死体积百分比,较对照组减小(P<0.01)。结论缺血前吸入2%、3%七氟醚对大鼠局灶性脑缺血-再灌注损伤可产生保护作用。
作者 王海莲 周守静
机构地区 复旦大学附属华山医院麻醉科
出处 《临床麻醉学杂志》 CAS CSCD 2007年第1期51-52,共2页 Journal of Clinical Anesthesiology
关键词 七氟醚 预处理 脑缺血
分类号 R96 [医药卫生—药理学]
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参考文献8

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二级参考文献9

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共引文献33

同被引文献17

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  • 10Matei G, Pavlik R, McCadden T, et al. Sevoflurane improves electrophysiological recovery of rat hippocampal slice CA1 pyramidal neurons after hypoxia. J Neurosurg Anesthesiol, 2002,14:293-298.

引证文献3

二级引证文献16

临床麻醉学杂志
2007年 第1期

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