摘要
热休克蛋白(HSP)一直被描述为一种细胞内蛋白质在胞内发挥一系列生物学作用,参与细胞内蛋白质的折叠、装配、降解和修复过程。近年来,有研究发现HSP70能被主动释放到胞外,成为细胞外HSP70(extracellular HSP70,eHSP70),但关于其功能尚不清楚。循环HSP70水平与多种疾病进程密切相关。有研究发现暴露于物理和心理刺激源作用下,HSP70可能通过脂筏或Exosome介导的分泌途径释放到细胞外,作为一种生物活性因子影响多种疾病的进程。
Heat shock proteins （HSP） were first characterized as intracellular proteins, which function to limit protein aggregation, facilitate protein refolding, and chaperone proteins. Recently, it has been demonstrated that HSP70 are also found extracellularly （eHSP70）. Little is known about the potential function of extracellular HSP70 （eHSP70）. Circulating eHSP70 levels are found to increase substantially in the process of many diseases. It has been proposed that exposure to acute physical or mental stressors stimulates the release of eHSP70 via lipid raft or exosome-mediated mechanism and elevated eHSP70 serves as an active cytokine and influence the process of disease.
出处
《医学分子生物学杂志》
CAS
CSCD
2007年第1期27-29,共3页
Journal of Medical Molecular Biology
基金
国家自然科学基金重点项目(No.30430590)~~
