摘要
本文将水溶性良好的凌甲基-β-CD（CM-β-CD）用于分离氯霉素中间体（CPM），考察了CM-β-CD作为毛细管电泳手性选择剂的分离性能。同时研究了pH值、CM-β-PCD浓度以及甲醇对分离的影响，并比较了CM-β-CD与β-CD分离CPM时的作用机理。
The water soluble 2, 6-di-O-carboxymethyl-β-cyclodextr (CM-β-CD) was used as a chiral selector to separate chloramphenicol metabolite. The effects of pH and CM-β-CD concentration on the enantiomeric separation were investigated. The addition of an organic modifier(methanol) to the buffer led to deterioration of the enantiomeric separation. The results indicated that CM-β-CD was superior to β-CD for the separation of chloramphenicol metabolite and the interaction mechanisms of CM-β-CD and β-CD were compared.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
1996年第12期1387-1390,共4页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金
关键词
毛细管电泳
手性分离
羧甲基
Β-环糊精
Capillary electrophoresis, enantiomeric separation, 2, 6-di-O-carboxymethyl-β-cyclodextrin
