摘要
鞘内注射α2受体拮抗剂育亨宾（30μg／8μl）可明显抑制电针镇痛，作用维持15分钟，作用最强时痛阈降至佯针水平，此时，电针所引起的侧脑室灌流液中β-内啡肽含量的升高也被抑制，β-内啡肽含量降至佯针水平，而育亨宾本身对基础痛阈及灌流液中β-内啡肽含量均无影响。结果提示，电针镇痛其所引起的β-内啡肽的释放与脊髓α2受体的激活有关。
Yohimbine (30μg/8μl, ith ), an antagonist of α2-adrenergic receptor, can inhibit electroacupuncture-induced analgesia (EAA) for 15 min, with its biggest effect reducing the pain threshold of electroacupuncture (EA) to the level of sham electroacupuncture (SEA). Yohmbine also completely inhibit the increase of 3-endorphin in the push-pull liquids from ventriculus lateralis cerebri caused by EA. But yohirnbine itself produce no effect on pain threshold and the concentration of 3-endorphin. These results suggest that EAA and the increased release of β-endorphin caused by EA are related to the activation of α2-adrenergic receptor in the spinal cord
出处
《针刺研究》
CAS
CSCD
1996年第1期52-55,共4页
Acupuncture Research
