摘要
目的研究阿托伐他汀负荷量治疗对ACS患者急诊经皮冠状动脉介入治疗(PCI)术后炎症因子水平的影响。方法入选64例ACS患者随机分为阿托伐他汀常规量组和负荷量组。常规量组入院后30分钟内及术后每晚服阿托伐他汀10mg,负荷量组入院后30分钟内服阿托伐他汀80mg,术后连续3天服80mg,后改为每晚10mg,共观察14天。两组术前、术后3天、7天、14天分别抽血查高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、血浆纤溶酶原激活剂抑制物(PAI-1)和P选择素水平。结果第14天时阿托伐他汀负荷量组血清细胞因子水平显著低于常规量组,两组分别是hs-CRP(3.37±0.12)mg/Lvs(5.54±0.10)mg/L、IL-6(2.96±0.18)ng/Lvs(5.28±0.24)ng/L和PAI-1(6.57±0.24)ng/Lvs(7.33±0.57)ng/L,均P<0.05。起始3天负荷量较常规量对血脂水平无更大影响。结论阿托伐他汀负荷量较常规量能更显著抑制PCI术后的炎症反应,降低血清hs-CRP、IL-6、PAI-1和P选择素水平。
Objective To explore the impact of loading dose atorvastatin to the inflammatory cytokins＇ level in the acute coronary syndrome（ACS） patients who received percutaneous coronary intervention. Methods Sixty-four ACS patients were divided into two groups,normal atorvastatin dose group and atorvastatin loading dose group. The patients of normal dose group received atorvastatin 10 mg before PCI and subsequently 10 mg/d; the loading dose group received atorvastatin 80 mg before PCI and subsequently 80 mg/d for three days,then changed to 10 mg/d. The concentrations of high sensitive C reactive protein（hs-CRP） ,interleukin 6 （IL-6）, plasminogen activator inhibitor 1 （PAI-1） P-selectin were detected before PCI and on the 3d,7th 14th day after PCI. Results At the 14th day, the cytokins＇ concentrations of atorvastatin loading dose group were significantly lower than those normal dose groups respectively hs-CRP （3.37±0.12） mg/L vs （5.54±0.10） mg/L, IL-6 （2.96±0.18） ng/L vs （5.28±0.24） ng/L and PAI-1 （6.57±0.24） ng/L vs （7.33±0.57） ng/L（all P〈0.05）. The loading dose of atorvastatin can not greatly affect the level of blood fat. Conclusion The loading dose of atorvastatin can greatly repress the inflammatory reaction after PCI, thus greatly lowering the concentrations of hs-CRP,IL-6,PAI-1 and P-selectin.
出处
《临床荟萃》
CAS
北大核心
2007年第3期155-158,共4页
Clinical Focus
关键词
冠状动脉疾病
阿托伐他汀
经皮冠状动脉介入治疗
炎症趋化因子
coronary artery disease
atorvastatin percutaneous coronary intervention
inflammatory chemokine factors
