摘要
目的：由于维生素Ｄ（简称ＶＤ）中毒引起骨质硬化的病理尚不明了，特此设计ＶＤ中毒实验病理研究。材料和方法：青紫蓝兔６６只。肌肉注射大、中、小剂量ＶＤ３。取上、下肢各大关节（包括骨干）、脊柱、肺、肾、胃进行Ｘ线照片和病理切片。结果：各部位骨骼髓腔、骨骺、干骺和关节软骨下均有不同程度硬化，还出现骨膜下吸收，骨皮质增厚，皮质骨松化，骨膜反应等。病理证实骨质硬化均为骨内转移性钙沉积。其机制是ＶＤ中毒引起成骨细胞和骨髓细胞坏死后钙化，轻者骨小梁表面钙沉积，重者钙化充满于松质骨的髓腔。停药后６～１２周观察，转移性钙化不能被吸收，而被新生骨包埋在骨内。
Purpose:Experimentalpathologicalstudywascariedouttoinvestigateonthepatho-genesisofosteosclerosisinhypervitaminosisD.Materialsandmethods:VariousdosesofvitaminD3wasadministeredintramuscularlyto66bluepurplerabbits.Largejointsandboneshaftsoftheupperandlowerextremities,spine,lung,kidneyandstomachweretakenforX-rayandpathologicalstud-ies.Results:Variousdegreesofosteosclerosiswerenotedinmarrowcavities,epiphyses,metaphy-ses.Thickeningofbonyarticularsurfaces,subperiostealresorption,corticalthickening,corticalporosityandperiostealreactionwerealsonoted.Osteosclerosiswasasprovedbypathology,duetometastaticcalcifications,whichwereconsideredtobethesequelofnecrosisofosteoblasticandbonemarrowcelsduetovitaminDintoxication.Inmildcases,calciumdepositionwasfoundatthesur-faceofthetrabeculaewhileinseverecases,marrowcavitiesofthecancelousbonewerefiledoutwithcalcification.Folow-upobservation6-12weeksafterdiscontinuationofmedicationshowednoappreciableabsorptionofthemetastaticcalcification,whichwasembeddedinnewbone.Conclusion:TheessentialpathologicalcharacteristicsofosteosclerosisinvitaminDintoxicationwasfoundtobemetastaticcalciumdeposition.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
1996年第12期863-867,共5页
Chinese Journal of Radiology
关键词
维生素D中毒
骨硬化
骨质疏松
VitaminDPharmacology,clinicalOsteosclerosisOsteoporosisRa-diographyPathology
