摘要
目的分析皮肌炎，多发性肌炎伴发恶性肿瘤患者的临床情况。方法回顾性分析我院1991—2005年间45例皮肌炎，多发性肌炎伴发恶性肿瘤患者，分析其临床特点及肿瘤相关因素。结果313例皮肌炎，多发性肌炎患者中45例（14．38％）伴发恶性肿瘤，伴发的肿瘤主要为鼻咽癌、肺癌、乳腺癌，69％患者恶性肿瘤发现于皮肌炎的诊断之时。伴发肿瘤的高危因子包括皮肌炎的发病年龄晚（〉40岁）（P=0．0047，OR=0．186）及病程短（〈1年）（P=0．0033，OR=3．884）。结论皮肌炎，多发性肌炎常伴发恶性肿瘤，所合并肿瘤的类型广泛，但以鼻咽癌、肺癌、乳腺癌等为主。对于年龄〉40岁、病程〈1年的患者，应进行相关检查及监测以排除可能合并的恶性肿瘤。
Objective To investigate the clinical features of dermatomyositis and polymyositis associated with malignancy. Methods A retrospective study was performed of 313 patients with a diagnosis of dermatomyositis and polymyositis admitted to the First Affiliated Hospital of Sun Yat-sen University over a period of 15 years. The clinical characteristics and risk factors of cases associated with malignancy were analyzed. Results Among these 313 patients with dermatomyositis and polymyositis, the incidence of malignancy was 14.38% （ 45/313 ）. Of the 45 patients with malignancy, 69% （ 31/45 ） cancers were diagnosed at the same time as dermatomyositis and polymyositis, and the most common malignancies were nasopharyngeal carcinoma, lung cancer, and breast cancer. Statistical analyses revealed that the high risk factors of concomitant malignancy included an onset in older age （ 〉 40 years ） （ P = 0.0047, OR = 0.186 ） and a shorter disease history （ 〈 1 year ） （ P = 0.0033, OR = 3.884 ）. Conclusions These results provide evidence that dermatomyositis and polymyositis are frequently associated with a wide variety of cancers, particularly carcinoma of nasopharynx, lung, and breast. Patients over 40 years of age or with a disease history of less than 1 year should be screened for possible associated malignancy.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2007年第1期31-33,共3页
Chinese Journal of Dermatology
关键词
皮肌炎
鼻咽肿瘤
肺肿瘤
乳腺肿瘤
副肿瘤综合征
Dermatomyositis
Nasopharyngeal neoplasms
Lung neoplasms
Breast neoplasms
Syndromes, paraneoplastic
