摘要
目的研究补阳还五汤对脑缺血再灌注后脑梗死体积及病理学改变的影响。方法采用线栓法制作大鼠局灶性脑缺血再灌注模型。将健康雄性SD大鼠随机分为假手术组、模型组、补阳还五汤组。各组大鼠处死后行TTC和HE染色,测定脑梗死体积并观察病理学改变。结果补阳还五汤组大鼠缺血侧脑组织病理改变较模型组减轻,梗死体积均明显小于模型组(P<0.01)。结论补阳还五汤可使脑缺血再灌注后脑梗死体积缩小,病理学改变减轻,对脑缺血再灌注损伤有保护作用。
Objective To investigate the influence of Buyanghuanwu （BYHW） Decoction on cerebral infarct volume and pathological changes after cerebral ischemia and reperfusion. Methods The model of focal cerebral ischemia and reperfusion was made by thread embolism method. Healthy male SD rats were divided randomly into sham-operated group, model group and BYHW Decoction group. Infarct volume was detected by triphenyltetrazolium chloride （TTC） staining and pathological changes were observed microscopically in HE stained sections. Results In BYHW Decoction group, infarct volume was significantly smaller than that in model group （P〈0.01）, pathological changes were better than those in model group. BYNW Decoction could decrease the cerebral infarct volume and alleviate the pathological changes after cerebral ischemia and reperfusion. It possesses protective effect against cerebral ischemia-reperfusion injury.
出处
《中国中医药信息杂志》
CAS
CSCD
2007年第2期41-42,共2页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
补阳还五汤
脑缺血
脑梗死体积
Buyanghuanwu Decoction cerebral ischemia pathology cerebral infarct volume
