摘要
目的评价盐酸丁咯地尔对血管性痴呆患者血流动力学的影响及临床疗效。方法将64例血管性痴呆患者随机分为2组，治疗组（33例）给予盐酸丁咯地尔150—200mg，每日1次静脉滴注，对照组（31例）给予胞二磷胆碱750mg，每日1次静脉滴注；4周为1个疗程。应用简易智能状态检查量表（MMsE）、长谷川痴呆量表（HDS）、痴呆严重程度临床评定量表（WMS）评定认知功能、采用Barthel指数（BI）评价日常生活活动能力（ADL）以判定疗效，治疗前后采用经颅多普勒（TCD）检测大脑中动脉（VMACA）、大脑前动脉（VACA）、大脑后动脉（VPCA）、椎动脉（VVA）、基底动脉（VBA）的血管平均血流速度（VM）及搏动指数（PI）的变化。结果治疗组用药后认知功能明显改善（P〈0．05和P〈0．01），大脑中动脉、大脑前动脉、大脑后动脉、椎动脉、基底动脉的血管平均血流速度及搏动指数改善，与对照组比较差异有显著性（P〈0．05和P〈0．01）。结论盐酸丁咯地尔可提高血管性痴呆患者的脑血流量，降低血管阻力，明显改善血管性痴呆的认知功能、智能状态及提高生活质量。
Objective To observe the effect of buflomedil on vascular dementia and hemodynamics of patients with vascular dementia（VaD）. Methods 64 patients with VaD were randomly divided into two groups . The buflomedil group of 33 patients were treated with buflomedil 150 mg-200 mg, iv drop qd for 4 weeks, while the control group of 31 patients was treated with citicolinum 750mg. Then their MMSE,HDS,WMS ,BI were evaluated and the VM and PI in VMCA ,VACA ,VPCA ,VVA ,VBA were measured by TCD in both groups before and after treatment ,respectively. Results In buflomedil group the scores of MMSE,HDS,WMS ,BI were increased more than those in control group, with significant differences between the two groups（ P 〈 0.05 and P 〈 0.01 ）. The mean velocity and pulsatility index in the buflomedil group improved more significantly than those in the control group （ P 〈 0.05 and P 〈 0. 01 ）. Conclusion The buflomedil can improve the cerebral blood flow and is good for the cognition functional recovery in vascular dementia patients.
出处
《中国医药》
2007年第1期1-3,共3页
China Medicine
