摘要
目的:用毛细管色谱柱气相色谱方法建立8种残留溶剂的测定方法。方法:采用 DB-Wax(30 m×0.53 mm×1.00μm)毛细管柱,以氮气为载气,FID 检测,2次程序升温,直接进样,测定残留溶剂的含量。结果:在各自的浓度范围内具有良好的线性关系(所测试的8种溶剂的相关系数均为0.999以上),8种溶剂的3个浓度的平均回收率范围均在91.0%～106.2%,RSD 为2.2%～5.2%。结论:本方法简便,结果准确,重现性好,可用于多种残留溶剂的同时测定。
Objective： To establish a method for determination of the residues of 8 kinds of solvents by capillary gas chromatography. Method：The capillary column was DB -Wax （30 m × 0. 53 mm × 1.00 μm）. The carrier gas was nitrogen and FID as detector. The injector temperature was 200 ℃, and the detector temperature was 250 ℃. The initial column temperature was kept at 34 ℃ for 4min with an increase rate of 10 ℃ · min^-1 to 60 ℃ ,then 50 ℃ · min^-1 to 160 ℃ （sustained for 5 min）. The quantification of residual solvents was calculated by external standard method. Results：Under the above condition, there was good linear relationship in the concentration range measured, the recoveries and RSDs ranged from 91.0% to 106.2% and 2.2% to 5.2% ,respectively. Conclusion：The method is simple accurate and reproducible.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2007年第1期148-150,共3页
Chinese Journal of Pharmaceutical Analysis
关键词
气相色谱法
辛伐他汀
毛细管柱
残留溶剂
gas chromatography
simvastatin
capillary column
residual solvent
