摘要
目的合成新型抗过敏药盐酸奥洛他定。方法以对羟基苯乙酸和苯酞为原料 ,经亲核取代、脱水环合、Wittig反应、成盐制备盐酸奥洛他定。结果目标化合物的结构经氢谱、质谱确证 ,总收率约 5 9%。结论改进了合成路线 ,为进一步工业生产和临床应用打下基础。
Aim To synthesize a novel anti allergic agent olopatadine hydrochloride.Methods Starting from the starting material 4 hydroxyphenylacetic acid.Olopatadine hydrochloride was synthesized via nucleophilic substitution,cyclization,Wittig reaction,salt formation.Results The structure of the target compound was confirmed by MS, 1H NMR,the overall yield was 5.9%.Conclusions The synthetic process of olopatadine hydrochloride is improved and suitable for industrial manufacture.
出处
《中国药物化学杂志》
CAS
CSCD
2004年第6期363-364,367,共3页
Chinese Journal of Medicinal Chemistry
关键词
药物化学
制备
化学合成
盐酸奥洛他定
抗过敏
medicinal chemistry
preparation
chemical synthesis
olopatadine hydrochloride
antiallergic
