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TRAIL系统与肿瘤细胞的凋亡 被引量：2

TRAIL System and Apoptosis of Tumor Cells
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摘要 目的了解TRAIL及其受体的结构功能、凋亡途径及在临床肿瘤治疗中的应用前景。方法参阅国内外文献,就有关的研究资料做一综述。结果研究资料表明TRAIL是肿瘤坏死因子家族的新成员,能选择性诱导肿瘤细胞凋亡,而对大多数正常细胞无毒性作用,且与传统的放疗、化疗有协同作用,有可能成为一种新型抗肿瘤药物。结论TRAIL能诱导肿瘤细胞凋亡,在临床肿瘤治疗中有良好的应用前景。
作者 沈滟 赵大治
机构地区 河南科技大学医学院 河南科技大学第一附属医院
出处 《河南科技大学学报（医学版）》 2006年第4期318-320,共3页 Journal of Henan University of Science & Technology:Medical Science
关键词 TRAIL 受体 肿瘤 细胞凋亡
分类号 R730.5 [医药卫生—肿瘤]
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参考文献4

二级参考文献20

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共引文献28

同被引文献35

  • 1唐艳旻,张丽梅,杨世方,朱冰,崔俊生,贾慧.重组变构人TRAIL对非小细胞肺癌细胞的体外抑制作用[J].基础医学与临床,2005,25(6):512-516. 被引量：3
  • 2张梅春,胡成平,陈琼,杨红忠.rhTRAIL对耐顺铂人肺腺癌细胞凋亡的影响[J].中国肺癌杂志,2005,8(5):419-423. 被引量：4
  • 3施敏骅,余勇,钱斌,连一新,陈锐,杜紫燕,胡华成.TRAIL和抗肿瘤药物协同诱导非小细胞肺癌凋亡的实验研究[J].苏州大学学报（医学版）,2006,26(2):190-192. 被引量：5
  • 4冯长根,周汉生,唐艳平,沈滟.rsTRAIL诱导人肺癌细胞系A549的细胞凋亡表达谱变化研究[J].中国药学杂志,2006,41(9):675-678. 被引量：4
  • 5Wiley SR, Schooley K, Smolak PJ. Identification and characterization of a new member of the TNF family that induees apoptosis. Immunity, 1995, 3(6): 673- 682.
  • 6Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science, 1997,276(5309): 111-113.
  • 7Pan G, Ni J, Wei YF, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science, 1997, 277(5327): 815-818.
  • 8Marsters SA, Sheridan JP, Pitti RM, et al. A novel receptor for Apo2L/ TRAIL contains a truncated death domain. Curr Biol, 1997, 7(12): 1003-1006.
  • 9Emery JG, McDonnell P, Burke MB, et al. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem, 1998, 273(23): 14363-14367.
  • 10Trabzuni D, Famulski KS, Ahmad M. Functional analysis of tumor necrosis factor-ct-related apoptosis-inducing ligand (TRAIL): cysteine-230 plays a critical role in the homotrimerization and biological activity of this novel tumoricidal cytokine. Biol Chem, 2000, 350(2): 505-510.

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河南科技大学学报（医学版）
2006年 第4期

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