摘要
目的探讨抗精神病药与强迫症状的关系。方法采用自编调查表对659例门诊精神分裂症病人做问卷调查并对病史资料进行统计分析。结果(1)精神分裂症伴强迫症状者122例,占18.5%(122/659),其中63例强迫症状在服用抗精神病药后出现,占9.6%(63/659);(2)非典型抗精神病药诱发强迫症状的比率依次为氯氮平14.2%,利培酮5.1%,奥氮平1.9%,经典抗精神病药诱发强迫症状的比率共计2.8%;(3)氯氮平高剂量者强迫症状的发生率高于低剂量者,约1/3的病人强迫症状出现在服用氯氮平1年以内,半数以上出现在服氯氮平3年以内。结论抗精神病药诱发的强迫症状并不少见,氯氮平是其中的常见药物,强迫症状的发生与用药剂量和时间有关。
Objective： To study the relationship between antipsychotics and obsessive -compulsive symptoms. Methods： 659 outpatients with schizophrenia and their case records were assessed with investigation list made by self. Results： （ 1 ） There are 122 cases（ 122/659,18.5% ） with OCS, 63 of which occur after taking antipsychotics, 9.6% （63/659）. （2） The ratio of atypical antipsychotics causing OCS is clozapine 14. 2%, risperidone 5.1%, olanzapinel. 9% respectively. The ratio of typical antipsychotics is 2.8%. （ 3 ） The incidence of OCS cases who heavily dosed with clozapine is higher than those lightly dosed . After taking clozapine, approximately OCS of 1/3 cases occurred within one year, and more than a half cases occurred within three years. Conclusion： OCS caused by antipsychotics is not seldom , clozapine is one of the common factors of causing OCS. The incidence of OCS related to dose and time segment of antipsychotics.
出处
《上海精神医学》
2006年第6期346-348,共3页
Shanghai Archives of Psychiatry
关键词
抗精神病药
强迫症状
精神分裂症
Antipsycbotics Obsessive - compulsive symptoms Schizophrenia
