摘要
用实体显微装置录像系统，观察了川芎嗪对麻醉蛙肺微循环的影响，结果表明：川芎嗪具有舒张肺微动脉，降低其阻力，促进肺微循环血流的作用．且有较好的剂量依赖关系．０．０１～１０ｍｍｏｌ·Ｌ－１川芎嗪ｉｖ７ｍｉｎ时，加快肺动脉血流的作用最强，ｉｖ后１０ｍｉｎ时，舒张肺微动脉作用最强．
The effects of tetramethylpyrazine (TMP) on pulmonary microcirculation were studied in exposed lung of bullfrogs by observing directly the blood flow in the pulmonary capillary network. The results indicate that TMP causes vasodilation in pulmonary microcirculation in vivo , and the effects are directly proportional to the dosages of the drug. When TMP (0.01 10.0 mmol·L -1 ) was injected intravenously into the bullforg, the blood flow velocity reached a maximum in 7 min, and arteriole diameter reached a maximum in 10 min.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1996年第3期193-195,共3页
Chinese Journal of Pharmacology and Toxicology
关键词
川芎嗪
肺微循环
中药药理学
tetramethylpyrazine
microcirculation, pulmonary
blood flow velocity
arterioles
