摘要
目的探讨钬激光在治疗肾实质肿瘤中的应用。方法制作兔的肾VX2肿瘤模型,超声影像学技术初步评估肿瘤组织的大小,在手术直视下,应用不同的钬激光照射参数,对肿瘤组织进行照射。通过肉眼、光镜及图像处理软件,观察钬激光对肿瘤组织的生物学效应及范围。结果钬激光照射后肿瘤组织肉眼观察被完全凝固,分为汽化层、凝固坏死层、外围损伤层三层。HE染色可发现肿瘤细胞发生凝固性坏死,电镜下亦见到不可逆的破坏。切割带外围热损伤的宽度局限于0.4￣0.8mm(平均0.54mm)。激光功率与损伤的肿瘤组织大小存在正相关关系。结论钬激光对肾VX2肿瘤组织具有精确的汽化、切割、凝固效果,同时止血可靠,可以通过调整激光的功率控制毁损肿瘤组织的范围,可操作性强。可以用于肾实质肿瘤的临床治疗,也可在影像技术的引导下行穿刺介入治疗,或者通过腹腔镜下治疗,以及应用于保肾手术中的辅助切割。
[Objective] To investigate the effectiveness of Ho：YAG laser irradiation in the treatment of kidney tumors. [Methods] Ten New Zealand rabbits bearing VX2 kidney tumors were irradiated by Ho： YAG laser with certain parameter in vivo. The vaporized incision, coagulation,haemostatic effect and pathologic alteration of laser to tumor tissues were observed and measured. [Results] Tumor ceils underwent coagulation necrosis immediately after irradiation with Ho： YAG. There Were three layers after Ho： YAG laser irradiation （The layer of vaporization, coagulation necrosis and thermal damage）. The width of thermal damage and its controls were determined by computer image analysis. Tissues. There was a positive correlation between irradiation power and ablation effect.The control was easily handled. [Conclusion] The experiment indicates that Ho：YAG laser should be effective in the treatment of kidney tumors.
出处
《中国医学工程》
2006年第6期564-566,共3页
China Medical Engineering
关键词
钬激光
肾实质
肿瘤
外科手术
Ho
YAG laser
renal parenchyma
tumor
Surgical intervention
