摘要
目的了解噬血细胞综合征(HPS)患者血浆IL-18等细胞因子的水平及临床意义,探讨其在HPS发病机制中的作用。方法采取11例HPS患者静脉血,酶联免疫吸附法(ELISA)检测血浆中IL-18、肿瘤坏死因子-α(TNF-α)、IL-6及IL-12的浓度。结果11例患者的IL-18、TNF-α、IL-6、IL-12水平明显高于正常对照组,细胞因子水平与临床表现有一定相关性,IL-18较高的A组(>150ng/L)与水平较低的B组(<150ng/L)患者在病因、肝功能异常和出血倾向方面有明显差异。结论IL-18细胞因子参与了HPS的发病机制,IL-18的检测对于病因诊断、病情严重程度及预后都有一定的提示作用。
Objective： To explore the levels and clinical significance of the plasma interleukin-18 （II.-18） and other eytokin＇es in the patients with Hemophagocytic syndrome （HPS）, Method： By using enzyme-linked immunosorbent assay （ELISA）, levels of IL-18, tumor-necrosis faetor-α（TNF-α）, interleukin-6 （IL-6） and interleukin-12 （IL-12） were measured in eleven patients with H PS. Result.All eytokines levels were significantly higher in the patients compared with healthy control. There were correlations between plasma cytokine levels and clinical features. IL-18 levels also correlated with underlying disorders, liver function and hemorrhage. Conclusion：These cytokines may play important roles in the pathogenesis of HPS. IL-18 measurement may be useful for the diagnosis and evaluating severity of the disease.
出处
《临床血液学杂志》
CAS
2007年第1期14-15,18,共3页
Journal of Clinical Hematology
