摘要
目的探讨MR灌注成像对健康家猪定量测定肝脏血流量的可行性及准确性。方法在3.0TMR机上,分别对9头健康实验猪行多层MR灌注增强扫描,在主动脉、门静脉及肝脏设置感兴趣区,测量信号强度,绘制时间-信号强度曲线,并运用肝脏灌注分析软件计算肝脏各血流参数。结果肝脏灌注曲线的基线平稳,各脏器绘制的TIC形态具有一定规律。计算得肝动脉灌注量(HAP)为(35.42±0.04)ml·min-1·100ml-1,门静脉灌注量(PVP)为(121.54±0.37)ml·min-1·100ml-1,总肝灌注量(THBP)为(156.96±0.37)ml·min-1·100ml-1,门静脉灌注指数(PVI)为(77.43±11.53)%,平均通过时间(MTT)为(10.30±3.59)s,对比剂分布容积(DV)为(36.41±9.02)%。结论MR灌注成像可以对健康家猪肝脏进行准确的血流动力学测量。
Objective The purpose of our study was to investigate the feasibility and accuracy of quantifying the blood flow volume of liver in healthy pigs. Methods At a 3.0T MR scanner, dynamic multiple-section magnetic resonance （MR） scanning of liver was performed in 9 healthy pigs. The regions of interests （ROI） were set in aorta, portal vein and liver respectively, in which the signal intensity was measured. The time-signal intensity curve was drawn and liver perfusion parameters were counted using specialized liver perfusion analysis software. Results The baselines of the liver perfusion curves were stable, and regularity was revealed in the curves of corresponding organs. The hepatic artery perfusion, portal vein perfusion, total hepatic blood flow, portal vein perfusion index, distribution volume and mean transit time were （35.42±0.04）ml·min^-1·100ml^-1, （121.54±0.37）ml·min^-1·100ml^-1, （156.96±0.37）ml·min^-1·100ml^-1, （77.43±11.53）%, （10.30±3.59）s and （36.41±9.02）%, respectively. Conclusion It＇s feasible to quantitatively evaluate the hemodynamics of liver in healthy pigs at a 3.0T MR unit.
出处
《影像诊断与介入放射学》
2006年第6期267-270,共4页
Diagnostic Imaging & Interventional Radiology
基金
2003年广东省自然科学基金资助项目(项目编号31738)
关键词
肝脏灌注
磁共振成像
血流动力学
Liver perfusion
Magnetic resonance imaging
Hemodynamics
