摘要
对胃癌单抗ＭＧ７所识别的胃癌新的相关抗原ＭＧ７Ａｓ、ＴＡＧ７２、ＣＡ１９．９（均为ＩＲＭＡ法）进行了前瞻性规范的诊断试验对照研究，评价ＭＧ７Ａｇ及其联合应用诊断胃癌的价值。结果：ＲＯＣ曲线法选择ＭＧ７Ａｇ界值为７．５ｋＵ／Ｌ。ＭＧ７Ａｇ、ＴＡＧ７２、ＣＡ１９－９诊断胃癌的敏感性分别为４８．８％、４５．３％、３８．５％，无显著性差别（Ｐ＞０．０５）；３者特异性分别为９２．８％、９１．６％、９２．８％（Ｐ＞０．０５）。ＭＧ７Ａｇ与ＴＡＧ７２，ＣＡ１９－９诊断Ⅲ、Ⅳ期胃癌的敏感性显著高于Ⅰ、Ⅱ期，其中ＭＧ７Ａｇ分别为６９．６％和２７．３％。ＭＧ７Ａｇ是一种有价值的胃癌标志物，与ＴＡＧ７２或（和）ＣＡ１９－９联合应用可显著提高诊断胃癌的敏感性。
A standard clinical diagnostic test was carried out prospectively to evaluate the serological diagnostic effectiveness of a novel gastric tumor associated antigen MG7Ag(measured by IRMA)defined by murine monoclonal antibody MG7,and compared it with the established tumor markers TAG72 and CA19 9.Likewise the usefulness of in alone or in combination application of these markers was studied.It was found that using 7 5kU/L as cut off levels by ROC,the over all sensitivity of MG7Ag in diagnosing gastric cancer was 48 8%,which was superier to TAG72(45 3%) or CA19 9(38 4%),but there was no significant difference.The specificity of MG7Ag(92 8%) was equal to TAG72(91 6%)and CA19 9(92 8%).The sensitivity of MG7Ag is related to the stage of gastric cancer,as 27 3% in Ⅰ Ⅱ stage and 69 6% in ⅢⅣ stage.The data clearly indicated that MG7Ag is a valuable marker for gastric cancer and simultaneous measurement MG7Ag and TAG72 or CA19 9 might provide more effectiveness detection for gastic cancer than could be achieved by only using a single one.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1996年第5期326-329,共4页
Medical Journal of Chinese People's Liberation Army
