摘要
为探讨提高胃癌患者胃液中肿瘤相关抗原的检出率及早期胃癌检测的敏感性，应用以胃癌单克隆抗体的特异性和聚合酶链反应（ＰＣＲ）的高度敏感性相结合建立的免疫－ＰＣＲ检测胃液中肿瘤相关抗原ＭＧ７Ａｇ。结果胃癌３７例、慢性萎缩性胃炎８例、慢性浅表性胃炎４例及消化性溃疡８例，胃液中ＭＧ７Ａｇ阳性分别为３０例、２例、０例及１例，胃癌患者胃液中ＭＧ７Ａｇ的阳性检出率为８１．１％。
This paper reports an improved technique,the immuno polymerase chain reaction method,to assay tumor associated antigen, MG 7Ag, in gastric juice from gastric cancer sufferer,trying to evaluate the rate of detection for the antigen and thereby that for early gastric cancer. Results found MG 7Ag positive in 30/37 cases with gastric cancer, in 2/8 with chronic atrophic gastritis,in 0/4 with chronic superficial gastritis and in 1/8 with peptic ulcer, suggesting that using this technigue the positivity of MG 7Ag in gastric fluid of the patient rise to 81.1%, to be of value in gastric cancer diagnosis with high sensitivity and specificity.
出处
《中华消化内镜杂志》
1998年第6期353-354,共2页
Chinese Journal of Digestive Endoscopy
基金
国家自然科学基金
关键词
肿瘤相关抗原
聚合酶链反应
胃肿瘤
MG7AG
Gastric cancer Tumor associated antigen Immuno polymerase chain reaction
