摘要
目的探讨急性脑卒中致全身炎症反应(S IRS)、多器官功能障碍综合征(M ODS)病程中炎性因子水平的变化及意义。方法100例急性脑卒中患者根据病情变化分为单纯脑卒中组、S IRS组、M ODS组,采用酶联免疫吸附法测定各组患者入院第1、7、14天血清高敏C反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)水平,另选25例健康查体者作为对照组。结果M ODS组、S IRS组、单纯脑卒中组血清hsCRP、TNFα-、IL-6水平均明显高于对照组,且随病情加重逐渐升高。结论炎性因子过度表达在急性脑卒中致S IRS、M ODS发病机制中发挥重要作用,炎性因子持续升高提示预后不良。
[Objective] To investigate the changes of serum cytokines in systemic inflammatory response syndrome （SIRS） induced multiple organ dysfunction syndrome （MODS） in acute cerebral accident. [Methods] 100 acute cases were divided into three groups according to diagnostic criteria of SIRS and MODS. Enzyme linked immunosorbent assay method was used to measure serum C-reactive protein （CRP）, tumor necrosis factor （TNF-α） and interleukin-6 （IL-6） contents at the first day, the seventh day and the fourteenth day after acute cerebral accident. Another 25 healthy adults served as normal controls. [Results] The serum CRP, TNF-α and IL-6 levels were significantly higher in patients than those in the healthy controls, and they increased in quantity progress!very along with the seriousness of the diseases. [Conclusion] Overexpressed cytokines play an important role in systemic inflammatory, response syndrome induced MODS in acute cerebral accident. The progressive increase in cytokines indicate a poor prognosis.
出处
《山东医药》
CAS
北大核心
2007年第1期3-4,共2页
Shandong Medical Journal
基金
河北省卫生厅基金资助项目(05032)
