摘要
目的探讨我国白塞病(BD)的临床表现以及各系统受累的发生率。方法通过中国医院知识数据库(CHKD),以“白塞病”为关键词,对1994年至2004年发表的中文文章进行检索,提取其中有关白塞病患者的临床资料并进行汇总分析。结果共46项研究中的1996例BD患者进入本研究,其中男1144例,女852例,平均发病年龄为(33.8±12.2)岁,平均病程为(8.9±5.2)年。最常见的首发症状为口腔溃疡(66.8%)和结节红斑(21.5%),其次为生殖器溃疡、关节炎/关节痛及眼部病变。在整个病程中,最常见的临床表现为复发性口腔溃疡(98.4%)、生殖器溃疡(76.3%)、结节红斑和假性毛囊炎(69.0%)、眼部病变(34.8%)、关节炎/关节痛(30.0%)。胃肠道、血管、神经、心脏、肺、肾和血液系统也均可受累,发生率分别为8.8%、7.7%、6.5%、4.0%、2.2%、1.9%和0.8%。眼部病变及血管、心脏和神经系统的受累均为男性多见(39.9%vs27.9%,P<0.001,OR=1.715;11.8%vs2.2%,P<0.001,OR=5.947;5.4%vs2.1%,P<0.005,OR=2.661;8.0%vs4.5%,P<0.05,OR=1.845),而血液系统受累更多见于女性(0.4%vs1.3%,P<0.05,OR=0.305),胃肠道受累患者中男女相当(8.3%vs9.4%,P>0.05)。57.9%的患者表现为针刺反应阳性,绝大多数为男性(70%vs41.7%,P<0.001)。结论我国白塞病的发病年龄在30岁左右,男性不仅多见,病情也更为严重。白塞病的临床表现可以多种多样,在临床工作中应高度重视。
Objective To identify the sab-types and frequency of clinical features of Chinese patients with Behcet＇s disease. Methods All articles published in Chinese between 1994 and 2004 were searched within the Journal Library of China Hospital Knowledge Database. Behcet＇s disease was used as the key word for searching. Data were extracted and then analyzed. Results 1996 Patients from 46 studies were available for analysis, in which 1144 were males, 852 were females with the age （33.8±12.2） years. The course duration was （8.9±5.2） years. The most frequent manifestations at disease onset were oral aphthae（66.8%） and erythema nodosum（21.5%）, followed by genital aphthae, arthralgia/arthfitis and inflammatory ocular disorders. The common manifestations observed throughout the disease course were oral aphthae （98.4%）, genital aphthae（76.3%）, erythema nodosum and pseudo-folliculitis（69.0%）, inflammatory ocular disease（34.8%） and arthralgia/arthritis （30.0%）. Gastro-intestine, vessels, nerve, heart, lung, kidney and blood were also involved in these patients at the frequency of 8.8%, 7.7%, 6.5%, 4.0%, 2.2%, 1.9% and 0.8% respectively. Ocular as well as vascular, cardiac and nervous system involvement were more common in males than in females（39.9% vs 27.9%, P〈 0.001, OR=1.715; 11.8% vs 2.2%, P〈 0.001, OR=5.947; 5.4% vs 2.1%, P〈 0.005, OR=2.661; 8.0% vs 4.5%, P〈 0.05, OR=1.845）. Hematological involvement occurred more frequently in females than in males （0.,$% vs 1.3%, P〈0.05, OR=0.305）, while gastrointestinal involvement was equally common in both sexes （8.3% vs 9.4%, P〉0.05）. 57.9% patients presented positive pathergy test and most of them were males （70% vs 41.7%, P〈0.001）. Conclusions BD starts frequently around the beginning of the third decade and has a male predominance. BD is usually more severe in males than in females. BD in Chinese patients is characterized by a variety of clinical manifestations, but some of the features are not consersus with the medical literature.
出处
《北京医学》
CAS
2007年第1期10-12,共3页
Beijing Medical Journal
关键词
白塞病
临床特征
Behcet＇s disease Clinical features
