摘要
竹红菌乙素（ＨｙｐｏｃｒｅｌｌｉｎＢ，简称ＨＢ）属于脂溶性醌类光敏剂。本文采用近代ＥＳＲ实验技术，探讨了ＨＢ在ＴｒｉｔｏｎＸ—１００胶束非均相体系中光敏反应原初过程的特征。首先证明，在非均相体系中，ＨＢ仍具有产生１Ｏ２的作用，进而证实，ＨＢ通过电子传递亦能产生ＨＢ－，Ｏ２－和·ＯＨ自由基。结果发现，ＨＢ在非均相胶束体系中，上述活性中间体（１Ｏ２和自由基）的相对产额均显著高于均相体系值。这表明，在非均相体系中，ＨＢ光敏反应激发能转移和电子传递具有新的特点和规律。据此推测，ＨＢ在生物非均相体系中的光敏损伤作用将会有新的特征。
The photosensitizing phocess of Hypocrellin B (HB), a kind of liposoluble perylenequinonoid photosensitizer, is studied by using modem ESR techniques in Triton X-100 micellar system. The generation of 4 in heterogeneous system is confirmed, and the generation of HB-, O2- and· OH through electeron transfer is demonstrated as well Besides, it is found that the relative yields of active intermediates(1O2 and free radicals) in heterogeneous system is much higher than that in homogeneous system. This indicates that the process of energy and electron transfer in heterogeneous system possesses new characters, which suggests in biological heterogeneous system, the photodynamic effect of HB will show new features.
出处
《生物物理学报》
CAS
CSCD
北大核心
1996年第2期345-349,共5页
Acta Biophysica Sinica
基金
国家自然科学基金
关键词
竹红菌乙素
竹红菌素
药物
非均相体系
光敏作用
Hypocrellin B
Triton X-100 micelle
Heterogeneous system
Photosensitization
ESR
